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Merck

C3630

Sigma-Aldrich

一水肌酸 一水合物

≥98%, suitable for cell culture

别名:

Creatine hydrate, Creatine, monohydrate, N-(aminoiminomethyl)-N-methyl-glycine hydrate

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About This Item

经验公式(希尔记法):
C4H9N3O2 · H2O
CAS号:
分子量:
149.15
Beilstein:
7942755
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.26

product name

一水肌酸 一水合物, ≥98%

品質等級

化驗

≥98%

形狀

powder

技術

cell culture | mammalian: suitable

顏色

white to off-white

mp

292 °C

SMILES 字串

O.CN(CC(O)=O)C(N)=N

InChI

1S/C4H9N3O2.H2O/c1-7(4(5)6)2-3(8)9;/h2H2,1H3,(H3,5,6)(H,8,9);1H2

InChI 密鑰

MEJYXFHCRXAUIL-UHFFFAOYSA-N

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應用

肌酸 (Cr) 和磷酸肌酸 (PCr) 主要通过(多种)肌酸激酶的作用参与骨骼肌组织中 ATP 的快速生成。肌酸可作为补充,以研究其摄取机制和操作代谢。

生化/生理作用

肌酸是一种含氮化合物,充当 ATP 快速再生的高能量储存库。大约 95% 的肌酸存在于骨骼肌中,主要为磷酸肌酸。肌酸可通过饮食摄入获得,也可由 L-精氨酸、甘氨酸和 L-蛋氨酸在肾脏和肝脏发生的多步骤反应中形成。肌酸随后被转运至肌肉组织。肌酸补充用于增强运动表现,主要是通过增加肌肉量。肌酸还被研究用于治疗神经肌肉疾病,可能有助于神经保护和改善细胞生物能量状态。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Clare E Turner et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(4), 1773-1780 (2015-01-30)
Impairment or interruption of oxygen supply compromises brain function and plays a role in neurological and neurodegenerative conditions. Creatine is a naturally occurring compound involved in the buffering, transport, and regulation of cellular energy, with the potential to replenish cellular
Domenic A LaRosa et al.
Pediatric research, 80(6), 852-860 (2016-07-29)
Maternal antenatal creatine supplementation protects the brain, kidney, and diaphragm against the effects of birth asphyxia in the spiny mouse. In this study, we examined creatine's potential to prevent damage to axial skeletal muscles. Pregnant spiny mice were fed a
Ignazio Maggio et al.
Scientific reports, 6, 37051-37051 (2016-11-16)
Mutations disrupting the reading frame of the ~2.4 Mb dystrophin-encoding DMD gene cause a fatal X-linked muscle-wasting disorder called Duchenne muscular dystrophy (DMD). Genome editing based on paired RNA-guided nucleases (RGNs) from CRISPR/Cas9 systems has been proposed for permanently repairing faulty
Yohei Tomita et al.
Diabetologia, 64(1), 70-82 (2020-10-26)
Proliferative diabetic retinopathy (PDR) with retinal neovascularisation (NV) is a leading cause of vision loss. This study identified a set of metabolites that were altered in the vitreous humour of PDR patients compared with non-diabetic control participants. We corroborated changes
Francis L Pazini et al.
Molecular neurobiology, 53(10), 6818-6834 (2015-12-15)
Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid remission, but elicits some side effects that limit its use. In an attempt to investigate a safer compound that may afford an antidepressant effect similar to ketamine

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