品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
white
溶解度
H2O: <2 mg/mL
DMSO: >7 mg/mL
儲存溫度
2-8°C
SMILES 字串
FC(F)(F)c1cccc(Nc2ccnc(Nc3cccc(NC(=O)C4CC4)c3)n2)c1
InChI
1S/C21H18F3N5O/c22-21(23,24)14-3-1-4-15(11-14)26-18-9-10-25-20(29-18)28-17-6-2-5-16(12-17)27-19(30)13-7-8-13/h1-6,9-13H,7-8H2,(H,27,30)(H2,25,26,28,29)
InChI 密鑰
RDTDWGQDFJPTPD-UHFFFAOYSA-N
生化／生理作用
ATP-competitive Aurora A kinase inhibitor with IC50 = 42 nM
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Pooja Mohan et al.
Oncotarget, 4(1), 80-93 (2013-01-19)
Malignant peripheral nerve sheath tumours (MPNST) are rare, hereditary cancers associated with neurofibromatosis type I. MPNSTs lack effective treatment options as they often resist chemotherapies and have high rates of disease recurrence. Aurora kinase A (AURKA) is an emerging target
Igor Astsaturov et al.
Science signaling, 3(140), ra67-ra67 (2010-09-23)
Intrinsic and acquired cellular resistance factors limit the efficacy of most targeted cancer therapeutics. Synthetic lethal screens in lower eukaryotes suggest that networks of genes closely linked to therapeutic targets would be enriched for determinants of drug resistance. We developed
Mahendra K Singh et al.
Cancer research, 70(21), 8907-8916 (2010-10-14)
Elevated expression of the NEDD9/HEF1/Cas-L scaffolding protein promotes tumor cell invasion and metastasis in multiple cancer cell types. Conversely, generation of mammary tumors in the mouse mammary tumor virus (MMTV)-polyoma virus middle T (PyVT) genetic model is delayed by a
Ming Shen Tham et al.
Nature communications, 15(1), 371-371 (2024-01-09)
Aurora Kinase A (AURKA) promotes cell proliferation and is overexpressed in different types of polycystic kidney disease (PKD). To understand AURKA's role in regulating renal cyst development we conditionally deleted the gene in mouse models of Autosomal Dominant PKD (ADPKD)
Qiong Zhang et al.
Journal of the American Chemical Society, 128(7), 2182-2183 (2006-02-16)
The epidermal growth factor receptor (EGFR) tyrosine kinase was one of the first receptor tyrosine kinases to be targeted for drug development by the pharmaceutical industry due to its ubiquitous overexpression in a variety of tumors. Despite the validation of
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