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Merck

A5508

Sigma-Aldrich

腺苷5′-磷酸硫酸盐 钠盐

≥85%

别名:

APS

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About This Item

经验公式(希尔记法):
C10H14N5O10PS
分子量:
427.28
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

生物源

synthetic (organic)

化驗

≥85%

形狀

powder

文件

see Safety & Documentation for available documents

食物過敏原

no known allergens

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OS(O)(=O)=O)C(O)C3O

InChI

1S/C10H14N5O10PS.Na.H/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22);;

InChI 密鑰

KLZADYTZAADWRW-UHFFFAOYSA-N

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應用

腺苷 5′-磷酸硫酸钠盐已被用于酶链生物发光检测法定量测定三磷酸腺苷(ATP) 和焦磷酸盐。

生化/生理作用

腺苷5′磷酸硫酸盐 (APS) 可用作三磷酸腺苷(ATP)硫酸化酶的底物,从而在萤火虫荧光素酶ATP发光分析和其他焦磷酸盐再生依赖型检测分析中,完成指数式ATP扩增中的PP(i)-循环回路。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Defective extracellular pyrophosphate metabolism promotes vascular calcification in a mouse model of Hutchinson-Gilford progeria syndrome that is ameliorated on pyrophosphate treatment
Villa BR, et al.
Circulation, 127(24), 2442-2451 (2013)
Novel bioluminescent assay of alkaline phosphatase using adenosine-3?-phosphate-5?-phosphosulfate as substrate and the luciferin-luciferase reaction and its application
Arakawa H, et al.
Analytical biochemistry, 314(2), 206-211 (2003)
Norbert Kiss et al.
Lasers in medical science, 35(8), 1821-1830 (2020-05-07)
Pseudoxanthoma elasticum (PXE, OMIM 264800) is a rare autosomal recessive disorder with ectopic mineralization and fragmentation of elastin fibers. It is caused by mutations of the ABCC6 gene that leads to decreased serum levels of inorganic pyrophosphate (PPi) anti-mineralization factor.
Fumika Mi-Ichi et al.
PLoS neglected tropical diseases, 13(8), e0007633-e0007633 (2019-08-20)
Amoebiasis, caused by Entamoeba histolytica infection, is a global public health problem. However, available drugs to treat amoebiasis are currently limited, and no effective vaccine exists. Therefore, development of new preventive measures against amoebiasis is urgently needed. Here, to develop
Kenji Tanimura et al.
Blood, 125(18), 2835-2844 (2015-03-04)
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thrombosis and/or pregnancy complications. β2-glycoprotein I (β2GPI) complexed with phospholipid is recognized as a major target for autoantibodies in APS; however, less than half the patients with clinical manifestations of APS

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