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化驗
≥98% (HPLC)
形狀
solid
顏色
off-white
溶解度
H2O: 27 mg/mL
儲存溫度
2-8°C
SMILES 字串
Br[H].Br[H].Cc1nc(N)sc1CCN
InChI
1S/C6H11N3S.2BrH/c1-4-5(2-3-7)10-6(8)9-4;;/h2-3,7H2,1H3,(H2,8,9);2*1H
InChI 密鑰
XFXNNOPUDSFVJE-UHFFFAOYSA-N
應用
Amthamine dihydrobromide is a histamine H2 receptor agonist. Amthamine dihydrobromide has been used to study the effect of mast cells on T regulatory cell function.
生化／生理作用
Amthamine dihydrobromide is a H2 histamine receptor agonist. Amthamine dihydrobromide, similar to histamine, inhibits H2 receptor-mediated eosinophil peroxidase (EPO) release with IC50 = 0.4 μM; a weak antagonist at H3 and shows no activity at H1 receptors.
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
G Coruzzi et al.
Naunyn-Schmiedeberg's archives of pharmacology, 348(1), 77-81 (1993-07-01)
The new histamine H2 receptor agonist amthamine, [2-amino-5-(2-aminoethyl)-4-methylthiazole], was tested for its activity on gastric acid secretion in different in vivo and in vitro experimental models. Amthamine induced a dose-related increase in acid secretion both in conscious cats with a
J C Eriks et al.
Molecular pharmacology, 44(4), 886-894 (1993-10-01)
Recently we developed amthamine [2-amino-5-(2-aminoethyl)-4-methylthiazole]. This cyclic analogue of dimaprit proved to be the most potent and selective histamine H2 receptor agonist of a series of substituted 4- or 5-(2-aminoethyl)thiazoles. Quantum chemical studies on histamine (N pi-H tautomer), dimaprit, and
J C Eriks et al.
Journal of medicinal chemistry, 35(17), 3239-3246 (1992-08-21)
It is well known that both histamine and dimaprit show moderate histamine H2-receptor agonistic activities on the guinea pig right atrium. Quantum chemical calculations on these two compounds showed similarities in electron distributions and molecular electrostatic potentials (MEP's), which could
E Poli et al.
Agents and actions, 40(1-2), 44-49 (1993-09-01)
The cardiac activity of the novel histamine H2-receptor agonist amthamine was investigated in a variety of isolated heart preparations from guinea pigs and humans and in the isolated rabbit aorta. Amthamine caused an increase in the sinus rate of spontaneously
Cardiac effects of amthamine: a new histamine H2-receptor agonist.
G Coruzzi et al.
European journal of clinical investigation, 25 Suppl 1, 27-28 (1995-03-01)
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