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Merck

A2269

Sigma-Aldrich

2-乙酰氨基芴

别名:

N-(2-芴基)乙酰胺, 2-AAF, 2-乙酰氨基芴, N-乙酰基-2-氨基芴

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About This Item

经验公式(希尔记法):
C15H13NO
CAS号:
分子量:
223.27
Beilstein:
2807677
EC 号:
MDL编号:
UNSPSC代码:
12352200

mp

192-196 °C (lit.)

SMILES字符串

CC(=O)Nc1ccc-2c(Cc3ccccc-23)c1

InChI

1S/C15H13NO/c1-10(17)16-13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9H,8H2,1H3,(H,16,17)

InChI key

CZIHNRWJTSTCEX-UHFFFAOYSA-N

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生化/生理作用

一种遗传毒性致癌物,用于诱发大鼠肝癌模型。当因肝脏中的细胞色素 CYP1A2 发生 N-羟基化时,2-AAF 与 DNA 形成加合物,在肝脏和膀胱中发生肿瘤。

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Yoshifumi Uno et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 182-187 (2015-07-28)
The data from the JaCVAM-organized international validation study of the in vivo rat alkaline comet assay were reported and analyzed statistically using the simple means of % tail DNA. However, OECD test guideline TG 489 recommends use of the median
Yoshifumi Uno et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 45-76 (2015-07-28)
The in vivo rodent alkaline comet assay (comet assay) is used internationally to investigate the in vivo genotoxic potential of test chemicals. This assay, however, has not previously been formally validated. The Japanese Center for the Validation of Alternative Methods
A R Kraynak et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 77-86 (2015-07-28)
As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM) initiative international validation study of the in vivo rat alkaline comet assay (comet assay), we examined the ability of the assay to determine the genotoxicity of 2-acetylaminofluorene

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