溶解度
0.1 M NaOH: 12 mg/mL
0.1 M HCl: 14 mg/mL
H2O: 5.2 mg/mL
methanol: insoluble
生化／生理作用
Potent and selective NMDA receptor agonist
其他說明
Note: Under IUPAC nomenclature, this compound is designated as trans
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
R D Allan et al.
Journal of medicinal chemistry, 33(10), 2905-2915 (1990-10-01)
We report the synthesis of a series of 3-carboxy-, 3-(carboxymethyl)-, 3-(omega-phosphonoalkyl)-1-aminocyclobutane-1-carboxylic acids for evaluation as agonists or antagonists of neurotransmission at excitatory amino acid receptors, particularly N-methyl-D-aspartic acid (NMDA) receptors. The compounds were evaluated as agonists on their ability to
Barbara Banelli et al.
Cell cycle (Georgetown, Tex.), 14(21), 3418-3429 (2015-11-15)
Notwithstanding current multimodal treatment, including surgery, radiotherapy and chemotherapy with temozolomide (TMZ), median survival of glioblastoma (GBM) patients is about 14 months, due to the rapid emergence of cell clones resistant to treatment. Therefore, understanding the mechanisms underlying chemoresistance is
Yuri Chikano et al.
Molecular cancer therapeutics, 14(2), 564-574 (2014-12-17)
The failure of current treatment options for glioblastoma stems from their inability to control tumor cell proliferation and invasion. Biologically targeted therapies offer great hope and one promising target is glycogen synthase kinase-3β (GSK3β), implicated in various diseases, including cancer.
Xiujuan Shi et al.
Molecular medicine reports, 11(5), 3533-3538 (2015-01-13)
Spindle and kinetochore‑associated protein 1 (SKA1) is an important component of the human kinetochore, which plays a key role in mitosis. The resent study was designed to investigate the role of SKA1 in human glioblastoma. The results of the present
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