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Merck

A123

Sigma-Aldrich

R-(+)-p-Aminoglutethimide (+)-tartrate salt

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About This Item

经验公式(希尔记法):
C13H16N2O2 · C4H6O6
CAS号:
分子量:
382.37
UNSPSC代码:
12352202
PubChem化学物质编号:

方案

99.4% (HPLC)

mp

124-127 °C

运输

ambient

SMILES字符串

O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC[C@@]1(CCC(=O)NC1=O)c2ccc(N)cc2

InChI

1S/C13H16N2O2.C4H6O6/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9;5-1(3(7)8)2(6)4(9)10/h3-6H,2,7-8,14H2,1H3,(H,15,16,17);1-2,5-6H,(H,7,8)(H,9,10)/t13-;1-,2-/m11/s1

InChI key

DQUXPVVSVXIQNE-IMXLTCNTSA-N

生化/生理作用

Inhibitor of aromatases involved in conversion of androgens to estrogens, and thus useful in chemotherapy of hormone-sensitive tumors (e.g., breast cancer). Also inhibits corticosteroid biosynthesis, termed a "medical adrenalectomy."

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Martina Dieber-Rotheneder et al.
Journal of the Society for Gynecologic Investigation, 13(6), 435-441 (2006-08-02)
This study tested the hypothesis that the endothelin (ET)/ET receptor (ETR) system in biologic fluids and in the human placenta is altered in delayed miscarriages as compared to apparently normal early pregnancies (reference group). Immunoreactive ET (irET) concentrations were measured
E J Sanford et al.
The Journal of urology, 115(2), 170-174 (1976-02-01)
Complete adrenal suppression with aminoglutethimide has been accomplished in 7 patients with progressive stage D carcinoma of the prostate who had become refractory to orchiectomy and the administration of exogenous estrogens. A favorable response was noted in 3 patients. These

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