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About This Item
经验公式（希尔记法）:
C5H11O8P · xNa+
CAS号:
分子量:
230.11 (free acid basis)
MDL编号:
UNSPSC代码:
12352201
PubChem化学物质编号:
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方案
≥95% (TLC)
表单
powder
储存温度
−20°C
SMILES字符串
[Na+].[P](=O)([O-])(OC[C@@H](O)[C@H](O)C(=O)CO)O
InChI
1S/C5H11O8P.Na/c6-1-3(7)5(9)4(8)2-13-14(10,11)12;/h4-6,8-9H,1-2H2,(H2,10,11,12);/q;+1/p-1/t4-,5-;/m1./s1
InChI key
OVHWWORCLJVDMI-TYSVMGFPSA-M
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生化/生理作用
D-Xylulose 5-phosphate (D-Xu-5-P) is a metabolite of the hexose monophosphate pathway activating protein phosphatase 2A to mediate the acute effects of carbohydrate feeding on the glycolytic pathway, the coordinated control of enzymes required in fatty acid & triglyceride synthesis. D-Xylulose 5-phosphate is the signal for the coordinated control of lipogenesis. The elevation of D-Xylulose 5-phosphate is the coordinating signal that both acutely activates phosphofructokinase in glycolysis and promotes the action of the transcription factor ChREBP to increase transcription of the genes for the enzymes of lipogenesis, the hexose mono-phosphate shunt, and glycolysis, all of which are required for the de novo synthesis of fat.
Xylulose-5-phoshate (Xu-5-P) is a metabolite of glucose via the pentose phosphate pathway. In the presence of excess glucose, liver Xu-5-P may act as a signaling molecule that regulates the nuclear transport of carbohydrate response element binding protein (ChREBP), a transcription factor that induces the expression of enzymes involved in glucose metabolism and lipogenesis.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type N95 (US)
J J Wang et al.
Alcoholism, clinical and experimental research, 21(4), 576-580 (1997-06-01)
Thiamine deficiency, a frequent complication of alcoholism, contributes significantly to the development of damage in various organ systems, including the brain. The molecular mechanisms that underlie the differential vulnerabilities to thiamine deficiency of tissue and cell types and among individuals
Susen Becker et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 883-884, 68-75 (2011-11-15)
The analysis of metabolites in human body fluids remains a challenge because of their chemical diversity and dynamic concentration range. Liquid chromatography (LC) in combination with tandem mass spectrometry (MS/MS) offers a robust, reliable, and economical methodology for quantitative single
Kostas Tsintzas et al.
Clinical science (London, England : 1979), 124(11), 675-684 (2013-01-16)
Physiological hyperglycaemia and hyperinsulinaemia are strong modulators of gene expression, which underpins some of their well-known effects on insulin action and energy metabolism. The aim of the present study was to examine whether acute in vivo exposure of healthy humans
Sigrun Langbein et al.
International journal of cancer, 122(11), 2422-2428 (2008-02-28)
Targeted therapies have demonstrated clinical benefit with limited impact on long-term disease specific survival in the treatment of renal cell cancer (RCC). New opportunities for the treatment of tumors that are resistant or have relapsed, are needed. Increased anaerobic glucose
S Langbein et al.
British journal of cancer, 94(4), 578-585 (2006-02-09)
Tumours ferment glucose to lactate even in the presence of oxygen (aerobic glycolysis; Warburg effect). The pentose phosphate pathway (PPP) allows glucose conversion to ribose for nucleic acid synthesis and glucose degradation to lactate. The nonoxidative part of the PPP
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