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Merck
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文件

53886

Sigma-Aldrich

Tn Antigen

≥99.0% (TLC), powder or crystals

别名:

, GalNac-α-1-O-serine

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About This Item

经验公式（希尔记法）:
C11H20N2O8
CAS号:
67262-86-6
分子量:
308.29
MDL號碼:
MFCD01863462
分類程式碼代碼:
12352204
PubChem物質ID:
329758013
NACRES:
NA.32

product name

Tn Antigen, ≥99.0% (TLC)

化驗

≥99.0% (TLC)

形狀

powder or crystals

儲存溫度

−20°C

SMILES 字串

CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@H](N)C(O)=O

InChI

1S/C11H20N2O8/c1-4(15)13-7-9(17)8(16)6(2-14)21-11(7)20-3-5(12)10(18)19/h5-9,11,14,16-17H,2-3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,7+,8-,9+,11-/m0/s1

InChI 密鑰

REDMNGDGDYFZRE-WKWISIMFSA-N

相关类别

一般說明

Tn 抗原是一种截短的 O -聚糖，在结直肠癌（CRC）中常见。通常在癌细胞中高水平表达。Tn 抗原体积小，结构简单。其在人体内具有非生理性聚糖结构，因此可能被免疫系统识别为异物。

生化／生理作用

Tn 抗原通过 H-Ras 介导的上皮间质转换刺激结直肠癌转移。作为几种重要复合物 O -聚糖的前体。携带 Tn 抗原的所有谱系中的血细胞亚群导致一种称为 Tn 综合征的血液疾病。

包裝

无底玻璃瓶。内含物装在插入式熔锥内。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Filip Kveton et al.
Sensors (Basel, Switzerland), 19(24) (2019-12-11)
The study describes development of a glycan biosensor for detection of a tumor-associated antibody. The glycan biosensor is built on an electrochemically activated/oxidized graphene screen-printed electrode (GSPE). Oxygen functionalities were subsequently applied for covalent immobilization of human serum albumin (HSA)
K Bergstrom et al.
Mucosal immunology, 10(1), 91-103 (2016-05-05)
Core 1- and 3-derived mucin-type O-glycans are primary components of the mucus layer in the colon. Reduced mucus thickness and impaired O-glycosylation are observed in human ulcerative colitis. However, how both types of O-glycans maintain mucus barrier function in the
Tianbo Gao et al.
Biochemical and biophysical research communications, 521(2), 514-520 (2019-11-05)
Aberrant O-glycosylation truncates O-glycans and is known to be closely associated with colorectal cancer (CRC), a major gastrointestinal tumor. CD44 is one of the highly post-transcriptionally modified O-glycoproteins participating in a series of physiological and pathobiological processes. In this research
Zhe Liu et al.
Journal of cellular and molecular medicine, 23(3), 2083-2092 (2019-01-15)
Tn antigen is a truncated O-glycan, frequently detected in colorectal cancer (CRC), but its precise role in CRC metastasis is not well addressed. Here we investigated the effects of Core 1 β3Gal-T specific molecular chaperone (Cosmc) deletion-mediated Tn antigen exposure
Lenneke A M Cornelissen et al.
Frontiers in oncology, 10, 1622-1622 (2020-10-06)
Expression of the tumor-associated glycan Tn antigen (αGalNAc-Ser/Thr) has been correlated to poor prognosis and metastasis in multiple cancer types. However, the exact mechanisms exerted by Tn antigen to support tumor growth are still lacking. One emerging hallmark of cancer
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