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Merck
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484R-1

Sigma-Aldrich

PRAME (EP461) Rabbit Monoclonal Primary Antibody

别名:

Preferentially-expressed Antigen in Melanoma

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About This Item

分類程式碼代碼:
12352203

生物源

rabbit

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

EP461, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (484R-14)
vial of 0.1 mL concentrate Research Use Only (484R-14-RUO)
vial of 0.5 mL concentrate (484R-15)
vial of 1.0 mL concentrate (484R-16)
vial of 1.0 mL concentrate Research Use Only (484R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (484R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (484R-17)
vial of 25.0 mL pre-dilute ready-to-use Research Use Only (484R-10-RUO)
vial of 25.0 mL pre-dilute ready-to-use (484R-10)
vial of 7.0 mL pre-dilute ready-to-use (484R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (484R-18-RUO)

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)

同型

IgG

控制

melanoma

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

nuclear

相关类别

一般說明

PRAME (PReferentially-expressed Antigen in MElanoma) is a gene encoded on the 22q11-22 chromosomal sequence and encodes a 509 amino acid residue protein.1 PRAME is a melanoma antigen that is preferentially expressed in tumors and is recognized by cytotoxic T lymphocytes.2,3 PRAME can be used to distinguish between malignant melanoma cells and nevus cells,4 and therefore may be useful for diagnostic purposes to support a suspected case of melanoma. PRAME is considered a cancer-testis antigen (CTA)5 and is not strongly expressed in most other normal tissues. PRAME is positively expressed in about half of uveal melanomas,6 and the majority of mucosal melanomas.7

品質

  • United States - IVD
  • Canada - RUO
  • European Union - IVD
  • Japan - RUO

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and < 0.1% Sodium Azide.

準備報告

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其他說明

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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Frances Wadelin et al.
Molecular cancer, 9, 226-226 (2010-08-31)
PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid
Aimi Toyama et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 32(12), 1727-1733 (2019-08-04)
Mucosal melanomas are rare, and less is known about the biomarkers of this subtype in comparison to cutaneous or uveal melanomas. Preferentially expressed antigen in melanoma (PRAME) has been studied as a tool for prognostication of uveal melanomas, and immunotherapy
H Ikeda et al.
Immunity, 6(2), 199-208 (1997-02-01)
Melanoma lines MEL.A and MEL.B were derived from metastases removed from patient LB33 in 1988 and 1993, respectively. The MEL.A cells express several antigens recognized by autologous cytolytic T lymphocytes (CTL) on HLA class I molecules. The MEL.B cells have
Cecilia Lezcano et al.
The American journal of surgical pathology, 42(11), 1456-1465 (2018-07-26)
PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen that was isolated by autologous T cells in a melanoma patient. While frequent PRAME mRNA expression is well documented in cutaneous and ocular melanomas, little is known about PRAME protein
Cecilia Lezcano et al.
The American journal of surgical pathology, 44(4), 503-508 (2019-10-22)
The distinction of metastatic melanoma from melanocytic nevi in lymph nodes can on occasion be difficult. As diffuse immunohistochemical (IHC) PRAME (PReferentially expressed Antigen in MElanoma) expression is detected in the majority of primary and metastatic melanomas, but rarely in
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