435R-1

MCM3 (EP202) Rabbit Monoclonal Primary Antibody

• UNSPSC代码: 12352202
• NACRES: NA.41

属性

• 生物来源: rabbit
• 偶联物: unconjugated
• 抗体形式: culture supernatant
• 抗体产品类型: primary antibodies
• 克隆: EP202, monoclonal
• 描述: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• 表单: buffered aqueous solution
• 种属反应性: human
• 包装: vial of 0.1 mL concentrate (435R-14); vial of 0.5 mL concentrate (435R-15); bottle of 1.0 mL predilute (435R-17); vial of 1.0 mL concentrate (435R-16); bottle of 7.0 mL predilute (435R-18)
• 制造商/商品名称: Cell Marque^®
• 技术: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
• 同位素/亚型: IgG
• 控制: tonsil
• 运输: wet ice
• 储存温度: 2-8°C
• 可视化: nuclear
• 基因信息: human ... MCM3(4172)

说明

一般描述

MCM3, minichromosome maintenance protein 3, belongs to the MCM family of highly conserved group of DNA-binding proteins known to have a role in the initiation and regulation of DNA replication during the cell cycle.^1-7 MCM3 expression is up-regulated in proliferating cells and absent in terminally differentiated cells. Like Ki-67, MCM3 marks proliferating cells. In a study performed by Endl E., et al., Ki-67 and MCM3 double staining was performed on human tonsil showing that MCM3 stains proliferating cells like Ki-67, and in addition marks cells present in the intermediate layer of epithelium (which are typically negative for Ki-67). Both Ki-67 and MCM3 are not detectable in differentiated cells.⁶ However, unlike Ki-67, MCM3 protein down-regulation is delayed. This suggests that Ki-67 may be expressed during a shorter interval of the cell cycle than MCM3. Anti-MCM3 may be a more reliable proliferation marker than anti-Ki-67.¹

质量

IVD

IVD

IVD

RUO

联系

MCM3 Positive Control Slides, Product No. 435S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: [email protected]

法律信息

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany