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Merck
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文件

241R-4

Sigma-Aldrich

Cyclin D1 (EP12) Rabbit Monoclonal Primary Antibody

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

EP12, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (241R-44)
vial of 0.5 mL concentrate (241R-45)
bottle of 1.0 mL predilute (241R-47)
vial of 1 mL concentrate (241R-46)
bottle of 7.0 mL predilute (241R-48)

製造商／商標名

Cell Marque™

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

dilution

1:100-1:500

同型

IgG

控制

mantle cell lymphoma

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

nuclear

基因資訊

human ... CCND1(595)

相关类别

一般說明

Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. Cyclins are proteins that govern transitions through distinct phases of the cell cycle by regulating the activity of the cyclin-dependent kinases. In mid-to-late G1 phase of the cell cycle, cyclin D1 shows a maximum expression following growth factor stimulation. Anti-cyclin D1 has been successfully employed and is a promising tool for further studies in both cell cycle biology and cancer associated abnormalities. This antibody is useful for separating mantle cell lymphomas (cyclin D1 positive) from chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphomas (cyclin D1 negative). Hairy cell leukemia and plasma cell myeloma can weakly express Cyclin D1.

品質


IVD
IVD
IVD
RUO

聯結

Cyclin D1 Positive Control Slides, Product No. 241S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

準備報告

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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J Bartkova et al.
Oncogene, 10(4), 775-778 (1995-02-16)
Cyclin D1 is a cell cycle regulator essential for G1 phase progression and a candidate proto-oncogene whose deregulated expression has been implicated in pathogenesis of several types of cancer. We have examined expression of cyclin D1 in 212 primary tumours
Y Yatabe et al.
Blood, 95(7), 2253-2261 (2000-03-25)
Mantle cell lymphoma (MCL) is a distinct clinicopathologic entity of non-Hodgkin's lymphoma, characterized by a monotonous proliferation of small to medium-sized lymphocytes with co-expression of CD5 and CD20, an aggressive and incurable clinical course, and frequent t(11;14)(q13;q32) translocation. We examined
Roman Kodet et al.
Virchows Archiv : an international journal of pathology, 442(6), 538-547 (2003-05-03)
Mantle cell lymphoma (MCL) is a clinicopathological entity characterized by an aggressive clinical course, morphological features, and overexpression of cyclin D1 due to juxtaposition of the bcl-1 locus (and CCND1 gene coding for the cyclin D1) to the IgH gene.
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue, 189-189 (2008)
J Bartkova et al.
The Journal of pathology, 172(3), 237-245 (1994-03-01)
Recent evidence from genetic studies suggests that abnormalities of some of the members of the cyclin superfamily may be intimately associated with tumourigenesis, most likely through deregulation of the cell cycle control. In an attempt to elucidate the potential role
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