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About This Item
经验公式（希尔记法）:
C12H15N3O3S
CAS号:
分子量:
281.33
Beilstein:
677664
MDL號碼:
分類程式碼代碼:
12352119
NACRES:
NA.77
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一般說明
Albendazole sulfoxide is a blood-brain barrier main metabolite of anti-parasitic agent albendazole that acts as a antihelminthic. It binds to colchicine binding site of β-tubulin and prevents polymerization. Albendazole sulfoxide exhibits greater affinity to parasitic β-tubulin than to mammalian.
應用
Metabolomics research
生化／生理作用
罗苯达唑是阿苯达唑的关键代谢产物，并作为驱虫药。研究表明，它可能通过使细胞周期停滞在 G2/M 期而诱导人癌细胞 HT-29 凋亡。
其他說明
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訊號詞
Warning
危險分類
Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1 - STOT RE 2 Oral
標靶器官
Adrenal gland,spleen,male reproductive organs,Blood
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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分析证书(COA)
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Lidia Radko et al.
Journal of veterinary research, 61(3), 313-319 (2018-07-07)
Albendazole is used to treat endoparasitic diseases in animals and humans. After oral administration, it is quickly oxidised into its pharmacologically active metabolite albendazole sulfoxide and then to sulfone. However, it is not clear which compound is responsible for toxic
Maximo Pettarin et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 155, 105552-105552 (2020-09-17)
The aim of this study was to use a combined in vitro-in silico approach to develop a physiologically based pharmacokinetic model (PBPK) that predicts the bioavailability of albendazole (ABZ), a BCS class II/IV lipophilic weak base, and simulates its main
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