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Merck
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主要文件

C2174000

西拉普利

European Pharmacopoeia (EP) Reference Standard

别名:

Cilazapril monohydrate

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About This Item

经验公式(希尔记法):
C22H31N3O5 · H2O
CAS号:
分子量:
435.51
MDL编号:
UNSPSC代码:
41116107
NACRES:
NA.24

等级

pharmaceutical primary standard

API类

cilazapril

制造商/商品名称

EDQM

应用

pharmaceutical (small molecule)

包装形式

neat

储存温度

2-8°C

SMILES字符串

N21N(CCC[C@H]2C(=O)O)CCC[C@@H](C1=O)N[C@@H](CCc3ccccc3)C(=O)OCC.O

InChI

1S/C22H31N3O5.H2O/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26;/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28);1H2/t17-,18-,19-;/m0./s1

InChI key

JQRZBPFGBRIWSN-YOTVLOEGSA-N

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

应用

Cilazapril EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包装

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他说明

Sales restrictions may apply.

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Milan R Radovanović et al.
Vojnosanitetski pregled, 66(11), 904-908 (2009-12-19)
Poisoning caused by drugs with cardiodepressive effects is an urgent condition in medicine which is associated with high mortality rate regardless of modern therapeutic methods. Accidental or intentional poisoning whit these drugs produces heart activity depression and cardiovascular collapse as
Spironolactone attenuates oxidative stress in patients with chronic kidney disease.
Marcin Renke et al.
Hypertension (Dallas, Tex. : 1979), 52(5), e132-e133 (2008-10-01)
Shih-Hsien Sung et al.
Journal of the Chinese Medical Association : JCMA, 71(5), 247-253 (2008-05-21)
Combined regimen may be superior to monotherapy in blood pressure (BP) control. Since BP control is critically related to cardiovascular mortality and morbidity in hypertensive patients, this study aimed to evaluate the efficacy and safety of a low-dose combined regimen
How controlling of hypertension might matter.
Kazuo Hara et al.
Circulation journal : official journal of the Japanese Circulation Society, 73(12), 2208-2209 (2009-11-27)
Nikola Radović et al.
Croatian medical journal, 49(5), 600-607 (2008-10-18)
To investigate the effects of angiotensin-converting enzyme inhibitor (cilazapril) and angiotensin II type I receptor antagonist (losartan) on tubular and interstitial cell apoptosis and caspase-3 activity in rats with obstructive nephropathy after unilateral ureteral obstruction. Rats with unilateral obstructive nephropathy

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