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Merck

89910

Supelco

Withaferin A

analytical standard

别名:

4β,5β,6β,22R)-5,6-环氧-4,22,27-三羟基-1-氧-麦角甾烷-2,24-二烯-26-油酸 δ-内酯, Withaferine

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About This Item

经验公式(希尔记法):
C28H38O6
CAS号:
分子量:
470.60
MDL號碼:
分類程式碼代碼:
85151701
PubChem物質ID:
NACRES:
NA.24

等級

analytical standard

品質等級

化驗

≥95.0% (HPLC)

儲存期限

limited shelf life, expiry date on the label

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

food and beverages

格式

neat

儲存溫度

2-8°C

SMILES 字串

C[C@H]([C@H]1CC(C)=C(CO)C(=O)O1)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H](O)C=CC(=O)[C@]6(C)[C@H]4CC[C@]23C

InChI

1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1

InChI 密鑰

DBRXOUCRJQVYJQ-CKNDUULBSA-N

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應用

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包裝

无底玻璃瓶。内含物装在插入的融合锥内。

其他說明

This compound is commonly found in plants of the genus: withania

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

438.8 °F

閃點(°C)

226 °C


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S Kushwaha et al.
Parasite immunology, 34(4), 199-209 (2012-03-08)
Withania somnifera is an ayurvedic Indian medicinal plant whose immunomodulatory activities have been widely used as a home remedy for several ailments. We recently observed immunostimulatory properties in the root extracts of chemotypes NMITLI-101, NMITLI-118, NMITLI-128 and pure withanolide, withaferin
Miranda Y Fong et al.
PloS one, 7(7), e42265-e42265 (2012-08-04)
Application of doxorubicin (Dox) for the treatment of cancer is restricted due to its severe side effects. We used combination strategy by combining doxorubicin (Dox) with withaferin A (WFA) to minimize the ill effects of Dox. Treatment of various epithelial
Abhinav Grover et al.
BMC genomics, 13 Suppl 7, S20-S20 (2013-01-11)
Leishmaniasis is caused by several species of leishmania protozoan and is one of the major vector-born diseases after malaria and sleeping sickness. Toxicity of available drugs and drug resistance development by protozoa in recent years has made Leishmaniasis cure difficult
Boris Grin et al.
PloS one, 7(6), e39065-e39065 (2012-06-22)
Withaferin A (WFA) is a steroidal lactone present in Withania somnifera which has been shown in vitro to bind to the intermediate filament protein, vimentin. Based upon its affinity for vimentin, it has been proposed that WFA can be used
Narayan D Chaurasiya et al.
Plant cell reports, 31(10), 1889-1897 (2012-06-27)
Withanolides are pharmaceutically important C(28)-phytochemicals produced in most prodigal amounts and diversified forms by Withania somnifera. Metabolic origin of withanolides from triterpenoid pathway intermediates implies that isoprenogenesis could significantly govern withanolide production. In plants, isoprenogenesis occurs via two routes: mevalonate

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