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Merck
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63174

Sigma-Aldrich

4-Maleimidobutyric acid

≥98.0% (T)

别名:

γ-Maleimidobutyric acid, 4-Maleimidobutanoic acid, N-(3-Carboxypropyl)maleimide, N-Maleoyl-4-aminobutyric acid, N-Maleoyl-GABA

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About This Item

经验公式（希尔记法）:
C8H9NO4
CAS号:
57078-98-5
分子量:
183.16
Beilstein:
1455876
MDL编号:
MFCD00043139
UNSPSC代码:
12352106
PubChem化学物质编号:
329759801
NACRES:
NA.25

质量水平

100

方案

≥98.0% (T)

mp

95-98 °C

SMILES字符串

OC(=O)CCCN1C(=O)C=CC1=O

InChI

1S/C8H9NO4/c10-6-3-4-7(11)9(6)5-1-2-8(12)13/h3-4H,1-2,5H2,(H,12,13)

InChI key

NCPQROHLJFARLL-UHFFFAOYSA-N

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应用

Gamma-maleimidobutyric acid may be used as a spacer in the construction of drug and other types of bioconjugates. 4-Maleimidobutyric acid is used with N-hydroxysuccinimide ester as a bifunctional cross-linking agent.
Modification reagent for thiol groups in proteins

其他说明

SH-label for the modification of peptides and proteins; Used for the preparation of a new bleomycin analog for enzyme immunoassay (EIA); probe for membrane SH-groups

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCBS9292V
BCBR2680V

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Biochemical Society Transactions, 11, 753-753 (1983)
K Fujiwara et al.
Cancer research, 41(10), 4121-4126 (1981-10-01)
An antibody directed toward pepleomycin, a new antitumor antibiotic related structurally to bleomycin, has been produced in rabbits by immunization with a pepleomycin-protein conjugate which was prepared by a novel procedure of coupling pepleomycin to mercaptosuccinylated bovine serum albumin using
Marie Pribylova et al.
International journal of pharmaceutics, 415(1-2), 175-180 (2011-06-15)
A new targeted conjugates in which paclitaxel was used as a cytostatic compound and an analog of the gonadotropin-releasing hormone (GnRH) as a targeting moiety were synthesized. The molecule of the peptide hormone GnRH was modified to allow its connection
Weibo Cai et al.
Nature protocols, 3(1), 89-96 (2008-01-15)
To take full advantage of the unique optical properties of quantum dots (QDs) and expedite future near-infrared fluorescence (NIRF) imaging applications, QDs need to be effectively, specifically and reliably directed to a specific organ or disease site after systemic administration.
Yuan Yuan et al.
Frontiers in bioscience : a journal and virtual library, 13, 3768-3774 (2008-05-30)
Development of sensitive and selective methods to detect proteins at trace levels is of great biological importance. Via derivatization with a bifunctional cross-linker 4-maleimidobutyric acid N-hydroxysuccinimide ester (GMBS) and an electrochemical marker 11-ferrocenyl-1-undecanethiol (Fc-SH), voltammetric determination of surface-confined proteins electrostatically
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