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Merck

37019

Supelco

阿托品

analytical standard

别名:

(8-甲基-8-氮杂双环[3.2.1]辛-3-基) endo-(+/-)-α-(羟甲基)苯乙酸酯, 莨菪碱, 龙葵碱

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About This Item

经验公式(希尔记法):
C17H23NO3
CAS号:
分子量:
289.37
Beilstein:
91260
EC號碼:
MDL號碼:
分類程式碼代碼:
85151701
PubChem物質ID:
NACRES:
NA.24

等級

analytical standard

儲存期限

limited shelf life, expiry date on the label

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

cleaning products
cosmetics
food and beverages
personal care

格式

neat

儲存溫度

−20°C

SMILES 字串

CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3

InChI

1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?

InChI 密鑰

RKUNBYITZUJHSG-SPUOUPEWSA-N

基因資訊

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一般說明

Atropine is an antimuscarinic drug, which is classified under the tropane alkaloid family of compounds.
Atropine is an antimuscarinic drug, which is classified under the tropane alkaloid family of compounds.
For the analysis of the phytotoxins.

應用

Atropine may be used as a reference standard for the determination of atropine in:
  • Blood samples by liquid chromatography combined with electrospray ionization-triple quadrupole mass spectrometry (LC-ESI-MS/MS).
  • Hair samples by ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) consisting of single-stage Orbitrap MS system with ESI interface.
  • Oganic buckwheat (Fagopyron esculentum L.) products by UHPLC-MS/MS.
  • Plant materials by liquid-liquid extraction and EXtrelut® column clean-up followed by analysis using gas chromatography (GC) coupled with flame ionization detector (FID) and MS.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Atropine may be used as a reference standard for the determination of atropine in:
  • Blood samples by liquid chromatography combined with electrospray ionization-triple quadrupole mass spectrometry (LC-ESI-MS/MS).
  • Hair samples by ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS) consisting of single-stage Orbitrap MS system with ESI interface.
  • Oganic buckwheat (Fagopyron esculentum L.) products by UHPLC-MS/MS.
  • Plant materials by liquid-liquid extraction and EXtrelut® column clean-up followed by analysis using gas chromatography (GC) coupled with flame ionization detector (FID) and MS.

生化/生理作用

位于中枢和外周毒蕈碱型乙酰胆碱受体处的竞争性非选择性拮抗剂。

重構

Dried down, ~100μg/mL after reconstitution with 1 mL of water

分析報告

purity : ≥96.0% (HPLC)

法律資訊

Extrelut is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 2 Inhalation - Acute Tox. 2 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析证书(COA)

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Isolation of atropine and scopolamine from plant material using liquid-liquid extraction and EXtrelut columns
<BIG>Sramska P, et al.</BIG>
Journal of Chromatography. B, Biomedical Sciences and Applications, 1043, 202-208 (2017)
Enantiomeric determination and evaluation of the racemization process of atropine in Solanaceae seeds and contaminated samples by high performance liquid chromatography-tandem mass spectrometry.
<BIG>Marin-Saez J, et al.</BIG>
Journal of Chromatography A, 1474, 79-84 (2016)
Are tropane alkaloids present in organic foods? Detection of scopolamine and atropine in organic buckwheat (Fagopyron esculentum L.) products by UHPLC-MS/MS.
<BIG>Cirlini M, et al.</BIG>
Food Chemistry, 239, 141-147 (2018)
High-throughput screening for drugs of abuse and pharmaceutical drugs in hair by liquid-chromatography-high resolution mass spectrometry (LC-HRMS).
<BIG>Odoardi S, et al.</BIG>
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 133, 302-310 (2017)
Method validation for simultaneous determination of atropine, pralidoxime and 12 organophosphorus compounds in blood samples by means of high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).
<BIG>Marques GLM, et al</BIG>.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1097, 44-53 (2018)

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