RV2MAG-26K
MILLIPLEX® Rat Vascular Injury Magnetic Bead Panel 2 - Toxicity Multiplex Assay
The analytes available for this multiplex kit are: Adiponectin, sE-Selectin, and sICAM-1.
别名:
Luminex® Rat Vascualr Injury Panel, Millipore Rat Vascualr Injury Panel, Rat Adiponectin Assay, Rat Vascular Injury Multiplex Assay
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About This Item
分類程式碼代碼:
12161503
eCl@ss:
32161000
NACRES:
NA.84
推荐产品
品質等級
物種活性
rat
製造商／商標名
Milliplex®
assay range
accuracy: 67-92%
standard curve range: 0.1-40 ng/mL
(sICAM-1)
standard curve range: 0.1-50 ng/mL
(sE-Selectin)
standard curve range: 0.3-250 ng/mL
(Adiponectin)
standard curve range: 0.7-500 ng/mL
(von Willebrand Factor (vWF))
技術
multiplexing: suitable
檢測方法
fluorometric (Luminex xMAP)
運輸包裝
wet ice
一般說明
Vascular injury is important to address during the preclinical safety study of drugs. A lack of well-defined mechanisms of drug-induced vascular injury (DIVI) in animals, and the absence of specific, qualified biomarkers have become significant barriers in the development of new therapeutic treatments. In the past, hemodynamics, such as heart rate and mean arterial blood pressure, were used to measure DIVI risks but these only targeted single biomarkers. Today, some of the known vascular injury mechanisms are related to vascular wall shear and/or circumferential “hoop” stress, drug/chemical toxicity, and immunological mediation. With these known biomechanics, primary targets (smooth muscle, endothelial and immune-mediated cells) yield a number of promising candidate biomarkers for DIVI study. We provide valuable research assays to investigate multiple biomarkers of vascular injury in rat serum and plasma samples using the Luminex® xMAP® instrument platform.
The MILLIPLEX® Rat Vascular Injury Bead Panel 2 contains all the components necessary to measure the following four biomarkers in any combination using Luminex® xMAP® technology: Adiponectin, sE-Selectin, sICAM-1, von Willebrand Factor (vWF). The kit uses a 96-well format, contains a lyophilized standard cocktail, two quality controls and can measure up to 38 serum or plasma samples in duplicate.
Panel Type: Toxicity
The MILLIPLEX® Rat Vascular Injury Bead Panel 2 contains all the components necessary to measure the following four biomarkers in any combination using Luminex® xMAP® technology: Adiponectin, sE-Selectin, sICAM-1, von Willebrand Factor (vWF). The kit uses a 96-well format, contains a lyophilized standard cocktail, two quality controls and can measure up to 38 serum or plasma samples in duplicate.
Panel Type: Toxicity
特異性
There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel.
應用
- Analytes: Adiponectin, sE-Selectin, sICAM-1, von Willebrand Factor (vWF)
- Recommended Sample type: serum and plasma
- Recommended Sample dilution: 1:80
- Assay Run Time: Overnight
- Research Category: Toxicity
特點和優勢
Design your multiplex kit by choosing available analytes within this panel.
包裝
Everything you need in a single kit.
儲存和穩定性
Recommended storage for kit components is 2 - 8°C.
其他說明
Please contact Technical Service for linearity of dilution.
Sensitivity: See kit protocol for individual analytes sensitivities.
法律資訊
Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
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了解在实验室、伴生和农业动物研究中使用生物标志物多重免疫检测产品的优势，探索MILLIPLEX®多重检测试剂盒在兽医学和动物健康研究方面的应用。
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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