MABT911F

Anti-Tspan-33 Antibody, clone 29A6.2 Antibody, FITC conjugate

clone 29A6.2, from mouse, FITC conjugate

• 别名: Tetraspanin-33, Penumbra, mPen, Proerythroblast new membrane
• UNSPSC代码: 12352203
• eCl@ss: 32160702
• NACRES: NA.43

属性

• 生物来源: mouse
• 偶联物: FITC conjugate
• 抗体形式: purified antibody
• 抗体产品类型: primary antibodies
• 克隆: 29A6.2, monoclonal
• 种属反应性: human, mouse
• 包装: antibody small pack of 25 μL
• 技术: flow cytometry: suitable
• 同位素/亚型: IgMκ
• NCBI登记号: NP_666285.1
• UniProt登记号: Q8R3S2
• 靶向翻译后修饰: unmodified
• 基因信息: mouse ... Tspan33(232670)

说明

一般描述

Tetraspanin-33 (UniProt: Q8R3S2; also known as Tspan-33, Penumbra, mPen, Proerythroblast new membrane) is encoded by the Tspan33 (also known as Pen) gene (Gene ID: 232670) in murine species. Tetraspanins are evolutionarily conserved proteins and thus far 33 of them have been described in human and murine species. Tspan-33 is a multi-pass, disulfide-linked homodimeric membrane protein of the tetraspanin (TM4SF) family. It has been reported that Tspan-33 is highly expressed in activated B cells. Its expression has also been reported in malignant B cells. Two isoforms of Tspan-33 have been described that are produced by alternative splicing. Tspan-33 plays an important role in normal erythropoiesis and in the differentiation of erythroid progenitors. Tspan-33 contains four transmembrane domains (aa 25-45, 65-85, 97-117, 236-256), three cytoplasmic domains (aa 1-24, 86-96, 257-283), and two extracellular domains (aa 46-64, 118-235). Several tetraspanins interact with specific membrane proteins via their second extracellular domain (aa 118-235) and incorporate them into tetraspanin-enriched microdomains to modulate the effectiveness of signal transduction by those membrane proteins. (Ref.: Luu, VP., et al. (2013). Clin. Immunol. 149(3): 388-399).

特异性

Clone 29A6.2 specifically detects Tspan-33 and targets an epitope with in the extracellular domain.

免疫原

BaF3 cells expressing full-length murine Tspan-33 fused with a Myc-His tag at the C-terminus.

Epitope: extracellular domain

应用

Anti-Tspan-33, clone 29A6.2, FITC conjugate, Cat. No. MABT911F, is a mouse monoclonal antibody that detects Tetraspanin-33 and has been tested for use in Flow Cytometry.

Research Category
Cell Structure

质量

Evaluated by Flow Cytometry in mouse splenocytes.

Flow Cytometry Analysis: 0.5 µg of this antibody detected Tspan-33 in 500,000 cells per mL mouse splenocytes.

目标描述

31.55 kDa calculated.

外形

Protein G purified

Purified mouse monoclonal antibody IgM in PBS with 0.1% sodium azide, with 1.5% BSA.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.