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Merck
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主要文件

MABS2214

Sigma-Aldrich

Anti-Extrahepatic biliary cells Antibody, clone hGB8

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

purified antibody

抗体产品类型

primary antibodies

克隆

hGB8, monoclonal

种属反应性

human

包装

antibody small pack of 100 μg

技术

flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

同位素/亚型

IgMκ

表位序列

Unknown

运输

ambient

靶向翻译后修饰

unmodified

一般描述

The gallbladder is a small, distensible pouch-like organ that concentrates and stores bile produced by the liver that helps break down dietary fats. Bile flows out of the liver via hepatic ducts that join with the cystic duct, which conveys bile to and from the gall bladder. Gallbladder is derived from the foregut endoderm during embryonic development. In an un-distended state, its mucosa appears to be thrown into many folds. Its lumen is lined with a high columnar epithelium. This epithelial layer rests on a highly vascularized lamina propria. The biliary epithelium shows a morphological heterogeneity that is strictly associated with a variety of functions performed at the different levels of the biliary tree. These epithelial cells are also involved in absorption of water and inorganic salts and help to concentrate bile. The connective tissue wall of gallbladder contains abundant elastic fibers and layers of smooth muscles that run obliquely. Between the smooth muscle layers and serosa lies a thick layer subserosal layer of connective tissue. The availability of antibodies that preferentially mark cell populations within the extrahepatic biliary system are useful for identification and classification of gallbladder cells in relation to bile physiology, gallstone formation, cell plasticity and renewal, metaplasia, and tumor formation. Clone hBG8 is reported to detect human gallbladder mucosal epithelium cells with subcellular localization.(Ref.: Galivo, FH., et al. (2015). Stem Cell Res. 15(1); 172-181).

特异性

Clone hGB8 is a mouse monoclonal antibody that detects subcellular mucosal epithelium in human gallbladder.

免疫原

Extrahepatic human biliary cells

应用

Quality Control Testing

Evaluated by Immunohistochemistry (Paraffin) in human gallbladder tissue sections.

Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected mucosal epithelium with subcellular localization in human gallbladder tissue sections.

Tested Applications

Immunofluorescence Analysis: A representative lot detected Extrahepatic biliary cells in Immunofluorescence applications (Galivo, F.H., et al. (2015). Stem Cell Res. 15(1):172-81).

Immunohistochemistry (Paraffin) Analysis: A representative lot detected Extrahepatic biliary cells in Immunohistochemistry applications (Galivo, F.H., et al. (2015). Stem Cell Res. 15(1):172-81).

Flow Cytometry Analysis: A representative lot detected Extrahepatic biliary cells in Flow Cytometry applications (Galivo, F.H., et al. (2015). Stem Cell Res. 15(1):172-81).

Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
Anti-Extrahepatic biliary cells, clone hGB8, Cat. No. MABS2214, is a mouse monoclonal antibody that detects subcellular mucosal epithelium in gallbladder and is tested in Flow Cytometry, Immunofluorescence, and Immunohistochemistry (Paraffin).

外形

Purified mouse monoclonal antibody IgM in PBS with 0.05% sodium azide.

储存及稳定性

Recommend storage at +2°C to +8°C. For long term storage antibodies can be kept at -20°C. Avoid repeated freeze-thaws.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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