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生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
N289/16, monoclonal
物種活性
human, mouse
物種活性（以同源性預測）
rat (immunogen homology)
技術
immunohistochemistry: suitable
western blot: suitable
同型
IgG1κ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... ABCC8(6833)
一般說明
Sulfonylurea receptor 1 (SUR1) is also called ATP-binding cassette sub-family C member 8, and is a member of the ABC transporter superfamily. SUR1 is a putative subunit of the beta-cell ATP-sensitive potassium channel (KATP) and functions as a regulator of ATP-sensitive K+ channels and insulin release.
特異性
This antibody recognizes the C-terminus of SUR1. Representative lot deteted Sur1 in crude brain membrane preparations
in SUR1 wild-type (WT) mouse cell lysate, and demonstrated a loss of signal in SUR1 knockout (KO) mouse cell lysate (Prof. J. Trimmer, University of California, Davis.).
in SUR1 wild-type (WT) mouse cell lysate, and demonstrated a loss of signal in SUR1 knockout (KO) mouse cell lysate (Prof. J. Trimmer, University of California, Davis.).
免疫原
Recombinant protein corresponding to the C-terminus of rat SUR1.
應用
Anti-SUR1 Antibody, clone N289/16 is a highly specific mouse monoclonal antibody, that targets SUR & has been tested in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected SUR1 in human thalamus tissue.
品質
Evaluated by Western Blotting in mouse hypothalamus tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected SUR1 in 10 µg of mouse hypothalamus tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected SUR1 in 10 µg of mouse hypothalamus tissue lysate.
標靶描述
~ 180 kDa observed
外觀
Format: Purified
分析報告
Control
Mouse hypothalamus tissue lysate
Mouse hypothalamus tissue lysate
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Ching-Han Lin et al.
The Journal of biological chemistry, 298(5), 101904-101904 (2022-04-11)
Pancreatic β-cells express ATP-sensitive potassium (KATP) channels, consisting of octamer complexes containing four sulfonylurea receptor 1 (SUR1) and four Kir6.2 subunits. Loss of KATP channel function causes persistent hyperinsulinemic hypoglycemia of infancy (PHHI), a rare but debilitating condition if not
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