MABD634

Anti-Retinal Dehydrogenase 1/ALDH1A1 Antibody, clone 16B4.2

clone 16B4.2, from mouse

• 别名: Retinal dehydrogenase 1, EC: 1.2.1.36, RALDH 1, RalDH1, ALDH-E1, ALHDII, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase, cytosolic
• UNSPSC代码: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物来源: mouse
• 抗体形式: purified immunoglobulin
• 抗体产品类型: primary antibodies
• 克隆: 16B4.2, monoclonal
• 种属反应性: human, rat
• 包装: antibody small pack of 25 μg
• 技术: immunohistochemistry: suitable (paraffin); western blot: suitable
• 同位素/亚型: IgG2bκ
• NCBI登记号: NP_000680
• UniProt登记号: P00352
• 靶向翻译后修饰: unmodified
• 基因信息: human ... ALDH1A1(216)

说明

一般描述

Retinal dehydrogenase 1 (UniProt: P00352; also known as EC: 1.2.1.36, RALDH 1, RalDH1, ALDH-E1, ALHDII, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase, cytosolic) is encoded by the ALDH1A (also known as ALDC, ALDH1, PUMB1) gene (Gene ID: 216) in human. Retinal dehydrogenase 1 is a ubiquitously distributed cytosolic enzyme that serves as a detoxification enzyme and also generates retinoic acid. It catalyzes the oxidation of retinal to retinoic acid that is essential for differentiation, development, and survival of dopaminergic neurons. It can also play a role in cellular defense against oxidative stress by oxidizing 4-hydroxynonenal (4-HNE) produced during lipid peroxidation. It is also involved in several other biological processes, such as stem cell maintenance, UV-radiation resistance, melanogenesis, and spermatogenesis, by catalyzing the conversion of specific aldehydes to their corresponding carboxylic acids. Retinal dehydrogenase 1 contains multiple NAD binding sites. (Ref.: Paval, D., et al. (2017). Clin. Psychopharmacol. Neurosci. 5(3); 229-236).

特异性

Clone 16B4.2 detects Retinal dehydrogenase 1/ALDH1A1. it targets an epitope with in 18 ammo acids from the C-terminal region.

免疫原

KLH-conjugated linear peptide corresponding to 18 amino acids from the C-terminal region of human retinal dehydrogenase 1.

应用

Anti-Retinal Dehydrogenase 1/ALDH1A1, clone 16B4.2, Cat. No. MABD634, is a mouse monoclonal antibody that detects Retinal Dehydrogenase 1 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.

Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution from a representative lot detected Retinal Dehydrogenase 1/ALDH1A1 in human liver and rat liver tissue sections.

Research Category
Neuroscience

质量

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Retinal Dehydrogenase 1/ALDH1A1 in human liver tissue lysate.

目标描述

~55 kDa observed; 54.86 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

外形

Protein G purified

Format: Purified

Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 储存分类代码: 12 - Non Combustible Liquids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable