推荐产品
生物源
mouse
品質等級
抗體表格
purified antibody
抗體產品種類
primary antibodies
無性繁殖
80.8.6, monoclonal
物種活性
human
技術
immunohistochemistry: suitable
inhibition assay: suitable
同型
IgG2aκ
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... SFRP2(6423)
一般說明
分泌型卷曲相关蛋白(SFRP)通过抑制Wnt/β-连环蛋白信号传导通路,可能在癌症发生中起关键作用。分泌型卷曲相关蛋白2(SFRP2)可用于研究乳腺肿瘤发生,因为在犬乳腺肿瘤中其表达随肿瘤的进展增加。研究发现小鼠胚胎中的SFRP2导致胸区严重变短。研究表明该蛋白是必需的干细胞旁分泌因子,该因子被认为是可以在缺血性损伤后调节心肌存活并修复损伤。
免疫原
KLH偶联的线性肽,对应于人SFRP2的NTR结构域。
表位:NTR 结构域
應用
抑制分析:抗-SFRP2(克隆80.8.6)抗体在体外抑制小管形成和SVR 血管肉瘤细胞的迁移,在体内抑制血管肉瘤和乳腺癌生长,并提高细胞核NFATc3水平。
抗-SFRP2抗体(克隆80.8.6, 不含叠氮化物)是一种针对SFRP2 的抗体,用于 IHC &抑制。
品質
通过免疫组化在人前列腺和人乳腺癌组织中进行了评估。
免疫组化分析:该抗体的1:500稀释液在人前列腺和人乳腺癌组织中检测到SFRP2。
免疫组化分析:该抗体的1:500稀释液在人前列腺和人乳腺癌组织中检测到SFRP2。
標靶描述
计算分子量为33 kDa
外觀
形式:纯化
其他說明
浓度:请参考批次特异性浓缩物的检验报告。
Not finding the right product?
Try our 产品选型工具.
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類(WGK)
WGK 2
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Nature, 532(7598), 250-254 (2016-04-05)
Cancer is a disease of ageing. Clinically, aged cancer patients tend to have a poorer prognosis than young. This may be due to accumulated cellular damage, decreases in adaptive immunity, and chronic inflammation. However, the effects of the aged microenvironment
Clinical cancer research : an official journal of the American Association for Cancer Research, 26(21), 5709-5719 (2020-10-25)
Angiogenesis is thought to be critical for tumor metastasis. However, inhibiting angiogenesis using antibodies such as bevacizumab (Avastin), has had little impact on melanoma patient survival. We have demonstrated that both angiogenesis and metastasis are increased in older individuals, and
Oncogene, 35(33), 4321-4334 (2016-01-12)
Most tumors initially respond to cytotoxic treatments, but acquired resistance often follows. The tumor microenvironment (TME) is a major barrier to clinical success by compromising therapeutic efficacy, and pathological relevance of multiple soluble factors released by a therapeutically remodeled TME
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门