MAB2641

Anti-Fibrillin (Pan) Antibody, clone 689

clone 689, from mouse

• 别名: EGF-containing fibulin-like extracellular matrix protein 1, Fibrillin-like protein, Extracellular protein S1-5
• UNSPSC代码: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物来源: mouse
• 质量水平: 100
• 抗体形式: purified immunoglobulin
• 抗体产品类型: primary antibodies
• 克隆: 689, monoclonal
• 种属反应性: mouse
• 种属反应性（根据同源性预测）: chicken (based on 100% sequence homology), human (based on 100% sequence homology)
• 技术: ELISA: suitable; immunohistochemistry: suitable
• 同位素/亚型: IgG1κ
• NCBI登记号: NP_115823
• UniProt登记号: Q75N90
• 运输: wet ice
• 靶向翻译后修饰: unmodified
• 基因信息: human ... EFEMP1(2202)

说明

一般描述

Fibrillins are glycosolated and disulfide-rich components of the extracellular matrix belonging to the Fibrillin-LTBP protein family. They serve an important function in both nonelastic and elastic tissues such as eye, bone and blood vessels. The functional units of Fibrillin are known as microfibrils, multiprotein assemblies, which act as structural scaffolding for the limiting of the tissue elasticity, structural integrity of different organ systems, the assembly of elastic fibers, and regulation of BMP growth factor signaling. There are three known isoforms; Fibrillin 1, Fibrillin 2, and Fibrillin 3. Fibrillin 3 is the most recently described member of the Fibrillin family, with highest expression in the brain. Alterations in the microfibril assembly often occur in patients with fibrillinopathies such as; Congenital Contractual Arachnodactyly (CCA) which results in disruption of Fibrillin 2, and Marfan’s syndrome resulting from Fibrillin 1 mutation.

特异性

The antibody recognizes isoforms 1, 2, and 3 of fibrillin.

免疫原

Recombinant protein corresponding to human Fibrillin 3.

应用

Anti-Fibrillin (Pan) Antibody, clone 689 detects level of Fibrillin (Pan) & has been published & validated for use in IH, ELISA.

ELISA Analysis: This antibody has been used by an independent laboratory in ELISA (Corson, 2003).

质量

Evaluated by Immunohistochemistry in fresh frozen mouse skin tissue.

Immunohistochemistry Analysis: 1:200 dilution of the antibody detected Fibrillin (Pan) in fresh frozen mouse skin tissue.

目标描述

~ 350 kDa calculated

外形

Format: Purified

分析说明

Control
Mouse skin tissue

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

安全信息

• 储存分类代码: 12 - Non Combustible Liquids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable