推荐产品
产品名称
Anti-Integrin β1 Antibody, clone HB1.1, clone HB1.1, Chemicon®, from mouse
生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
HB1.1, monoclonal
种属反应性
human, pig
制造商/商品名称
Chemicon®
技术
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
同位素/亚型
IgG1κ
适用性
not suitable for activity/function inhibition
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... ITGB1(3688)
特异性
Reacts with beta-1 subunit of VLA integrins
应用
Anti-Integrin β1 Antibody, clone HB1.1 detects level of Integrin β1 & has been published & validated for use in FC, IP, WB, IH.
Immunoprecipitation of VLA integrins from lysate of 10E6 cell equivalent requires 2 μg of MAB2000.
Flow cytometry: 10 μg/mL
Western blot
Immunohistochemistry in frozen tissue samples: 5 μg/mL
Induction of cell aggregation: 10 μg/mL. MAB2000 is a potent stimulator of cell aggregation tested in U937, Jurkat and human peripheral blood lymphocytes.
MAB2000 does not affect VLA integrin-mediated cell adhesion to matrix proteins.
Optimal working dilutions must be determined by end user.
Flow cytometry: 10 μg/mL
Western blot
Immunohistochemistry in frozen tissue samples: 5 μg/mL
Induction of cell aggregation: 10 μg/mL. MAB2000 is a potent stimulator of cell aggregation tested in U937, Jurkat and human peripheral blood lymphocytes.
MAB2000 does not affect VLA integrin-mediated cell adhesion to matrix proteins.
Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Integrins
Integrins
联系
Replaces: 04-1109
外形
Format: Purified
Purified immunoglobulin from Protein A chromatography. Liquid in 0.02M PB pH 7.6, 0.25M NaCl with 0.1% sodium azide.
储存及稳定性
Maintain at 2-8°C for up to 6 months after date of receipt.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Roland Thuenauer et al.
mBio, 11(2) (2020-03-12)
The opportunistic bacterium Pseudomonas aeruginosa produces the fucose-specific lectin LecB, which has been identified as a virulence factor. LecB has a tetrameric structure with four opposing binding sites and has been shown to act as a cross-linker. Here, we demonstrate
Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells.
Thapa, N; Sun, Y; Schramp, M; Choi, S; Ling, K; Anderson, RA
Developmental Cell null
Amy M Lum et al.
BMC cancer, 10, 40-40 (2010-02-13)
GPR110 is an orphan G protein-coupled receptor--a receptor without a known ligand, a known signaling pathway, or a known function. Despite the lack of information, one can assume that orphan receptors have important biological roles. In a retroviral insertion mutagenesis
Close homolog of L1 is an enhancer of integrin-mediated cell migration.
Buhusi, M; Midkiff, BR; Gates, AM; Richter, M; Schachner, M; Maness, PF
The Journal of Biological Chemistry null
D Oguey et al.
Gene therapy, 7(15), 1292-1303 (2000-08-05)
We explored the possibility of using a genetic approach to inhibit integrin-mediated endothelial cell adhesion and survival. We constructed recombinant adenoviruses (Ads) expressing chimeric proteins consisting of the cytoplasmic and transmembrane domains of integrin beta1 (CH1), beta3 (CH3) or the
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