生物来源
mouse
质量水平
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
102D1, monoclonal
种属反应性
human
制造商/商品名称
Chemicon®
技术
immunohistochemistry: suitable (paraffin)
western blot: suitable
同位素/亚型
IgG1
NCBI登记号
UniProt登记号
运输
wet ice
靶向翻译后修饰
unmodified
基因信息
human ... TIMP1(7076)
特异性
It recognizes a glycoprotein of 28.5 kDa which is identified as tissue inhibitor of metalloproteinases-1 (TIMP-1). TIMP-1 and TIMP-2 have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-1 forms a complex of 1:1 stoichiometry with activated interstitial collagenase, activated stromelysin, active form of 72 kDa type IV collagenase (also known as MMP-2 or gelatinase A), and latent and active forms 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMPs inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
Cellular Localization:
Cytoplasmic
Cellular Localization:
Cytoplasmic
免疫原
Recombinant human TIMP-1.
应用
Anti-TIMP-1 Antibody, clone 102D1 is an antibody against TIMP-1 for use in WB, IH(P).
Research Category
Cell Structure
Cell Structure
Research Sub Category
MMPs & TIMPs
MMPs & TIMPs
Western Blotting: 1-2 μg/mL for 2 hours at room temperature
Immunohistochemistry: Formalin-fixed, paraffin-embedded tissues: 1-2 μg/mL for 30 min. at room temperature.
Optimal working dilutions must be determined by end user.
Immunohistochemistry: Formalin-fixed, paraffin-embedded tissues: 1-2 μg/mL for 30 min. at room temperature.
Optimal working dilutions must be determined by end user.
外形
Format: Purified
Purified from ascites fluid by Protein G chromatography. Liquid in 10 mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide.
储存及稳定性
Maintain at 2-8°C in undiluted aliquots for up to 12 months after date of receipt.
分析说明
Control
POSITIVE CONTROL: Cytotrophoblastic columns, the endothelial and fibroblastic stromal cells of villi, and the large decidualized cells of decidual membrane in placenta1.
POSITIVE CONTROL: Cytotrophoblastic columns, the endothelial and fibroblastic stromal cells of villi, and the large decidualized cells of decidual membrane in placenta1.
其他说明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律信息
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Takahiko Naka et al.
Cancer, 112(1), 104-110 (2007-10-24)
Hepatocyte growth factor (HGF) is a multipotent cytokine that is mediated by its receptor, c-MET. HGF/c-MET contributes to tumor progression in many human malignancies; however, HGF/c-MET is inversely correlated with aggressive biologic behavior in other cancers. Conversely, to the authors'
Yuko Sugiyama et al.
Gastroenterology, 128(2), 480-486 (2005-02-03)
The surrounding cancer stroma is increasingly recognized as playing an important role in cancer proliferation, invasion, and metastasis. Here, we analyzed patterns of gene expression in colon cancer cells, surrounding stroma, and normal mucosa and normal stroma using laser capture
David Moreno-Ajona et al.
BMC cardiovascular disorders, 20(1), 93-93 (2020-02-27)
Major adverse cardiovascular events are the main cause of morbidity and mortality over the long term in patients undergoing carotid endarterectomy. There are few reports assessing the prognostic value of markers of inflammation in relation to the risk of cardiovascular
Alessia Frati et al.
Molecular endocrinology (Baltimore, Md.), 29(1), 53-67 (2014-11-22)
The initiation and progression of heart failure is linked to adverse cardiac remodeling of the extracellular matrix (ECM) during disease mainly through the deregulation of myocardial metalloproteinases (MMPs). Relaxin (RLX), a peptide hormone acting as a physiological cardiac effector, is
Pannatas Seanpong et al.
Japanese journal of infectious diseases, 68(3), 221-229 (2015-02-13)
Disease severities following dengue virus (DV) infection are the result of increased vascular permeability leading to hypovolemic shock. Matrix metalloproteinases (MMPs) are believed to play a key role in promoting such severities. A previous study reported that supernatants of DV-infected
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