跳转至内容
Merck
所有图片(2)

文件

HTMP2MAG-54K

Millipore

MILLIPLEX® Human TIMP磁珠板2-免疫学多重检测试剂

TIMP Bead-Based Multiplex Assays using the Luminex technology enables the simultaneous analysis of multiple TIMP biomarkers in human cell/tissue culture supernatant samples.

登录查看公司和协议定价


About This Item

分類程式碼代碼:
12161503
eCl@ss:
32161000
NACRES:
NA.84

品質等級

物種活性

human

製造商/商標名

Milliplex®

assay range

accuracy: 77-95%
standard curve range: 10-10,000 pg/mL
(TIMP-4)

standard curve range: 20-20,000 pg/mL
(TIMP-1)

standard curve range: 49-50,000 pg/mL
(TIMP-2)

standard curve range: 98-100,000 pg/mL
(TIMP-3)

技術

multiplexing: suitable

檢測方法

fluorometric (Luminex xMAP)

運輸包裝

wet ice

一般說明

金属蛋白酶(TIMP)的组织抑制剂包括一个四种抑制剂家族,分别称为TIMP-1,TIMP-2,TIMP-3和TIMP-4。TIMP家族的每个成员都有其独特的金属蛋白酶抑制作用。基质金属蛋白酶(MMPs)是锌蛋白酶家族,在正常的生理过程中参与细胞外基质(ECM)的分解,例如胚胎发育,组织和骨骼重塑,伤口愈合,组织形态发生,血管生成和肿瘤转移。还已知MMPs参与细胞表面受体的裂解,凋亡配体(例如FAS配体)的释放,细胞增殖,分化和趋化因子的激活。MMPs的正常功能必须通过其内源性蛋白抑制剂TIMPs精确调节。TIMP通过与MMP形成1:1非共价复合物来抑制MMP,从而阻断底物进入MMP催化位点。除抑制活性MMPs外,TIMPs还具有其他几种生化和生理/生物学功能,例如proMMP激活,促进细胞生长,基质结合,抑制血管生成和诱导细胞凋亡。MMP/TIMP平衡的破坏可导致严重的疾病,例如关节炎,心血管疾病,肿瘤生长和转移。

MILLIPLEX ®人TIMP面板2磁珠试剂盒(TIMP-1、-2、-3、-4)设计用于组织/细胞培养样品。

Luminex® xMAP®平台使用磁珠免疫分析格式,以实现理想的速度和灵敏度,同时定量多种分析物,从而显著提高生产力,同时节省宝贵的样品量。

面板类型:细胞因子/趋化因子

特異性

交叉反应性
在该面板中的分析物之间未观察到显著的交叉反应性。

應用

  • 分析物:TIMP-1、TIMP-2、TIMP-3、TIMP-4
  • 推荐的样品类型:组织和细胞培养物上清液
  • 分析运行时间:一日或过夜
  • 研究类别:炎症 & 免疫学

特點和優勢

通过在此面板中选择可用的分析物来设计多重试剂盒。

儲存和穩定性

试剂盒组分建议的存储温度为2-8°C。

其他說明

灵敏度:有关单个分析物的灵敏度,请参阅试剂盒方案。

法律資訊

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

象形圖

Exclamation markEnvironment

訊號詞

Warning

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

10 - Combustible liquids


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Larissa Berloffa Belardin et al.
Scientific reports, 9(1), 903-903 (2019-01-31)
Matrix Metalloproteinases (MMPs) and their regulators - Tissue Inhibitors of Matrix Metalloproteinases (TIMPs) - participate in extracellular matrix remodeling, fibrosis, and semen liquefaction, as well as to inflammatory activity. Seminal plasma has been shown to contain MMPs (MMP-2 and MMP-9)
Abstracts from the 43rd American Society of Andrology Annual Meeting, 21-24 April 2018, Portland, Oregon.
Andrology, 6 Suppl 1, 1-98 (2018-03-28)
Jonathan H Soslow et al.
Journal of cardiac failure, 25(4), 259-267 (2019-02-15)
Cardiomyopathy is the leading cause of death in Duchenne muscular dystrophy (DMD). Standard cardiac biomarkers are poor indicators of DMD cardiovascular disease. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) regulate collagen turnover. Given the cardiac fibrosis seen in
Julia E Herrmann et al.
Toxicology and applied pharmacology, 274(2), 302-312 (2013-11-30)
Human response to isoproterenol induced cardiac injury was evaluated by gene and protein pathway changes in human heart slices, and compared to rat heart slices and rat heart in vivo. Isoproterenol (10 and 100μM) altered human and rat heart slice
Preethi Vijayaraj et al.
Cell reports, 29(11), 3488-3505 (2019-12-12)
Progressive organ fibrosis accounts for one-third of all deaths worldwide, yet preclinical models that mimic the complex, progressive nature of the disease are lacking, and hence, there are no curative therapies. Progressive fibrosis across organs shares common cellular and molecular

相关内容

Immunoassays in cosmetics research assess product safety and effects on inflammation, aging, and tissue regeneration.

Immunology multiplex assays like MILLIPLEX® allow simultaneous investigation of immune biomarkers, saving time and resources in research.

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门