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Merck
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主要文件

ABS532

Sigma-Aldrich

Anti-TRIM63 Antibody

from rabbit, purified by affinity chromatography

别名:

E3 ubiquitin-protein ligase TRIM63, Iris ring finger protein, Ring finger protein 28, muscle-specific RING finger protein 1, muscle-specific RING finger protein 2, Tripartite motif-containing protein 63, Striated muscle RING zinc finger protein, TRIM63,

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

純化經由

affinity chromatography

物種活性

human

物種活性(以同源性預測)

bovine (based on 100% sequence homology)

技術

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

目標翻譯後修改

unmodified

基因資訊

human ... TRIM63(84676)

一般說明

TRIM63, also known as E3 ubiquitin-protein ligase TRIM63, Iris RING finger protein, Muscle-specific RING finger protein 1, MuRF-1, MuRF1, RING finger protein 28, Striated muscle RING zinc finger protein, Tripartite motif-containing protein 63, and encoded by the gene name TRIM63/ IRF/ MURF1/ RNF28/ SMRZ, is a E3 ubiquitin ligase. TRIM63 mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. It also regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. TRIM63 inhibits de novo skeletal muscle protein synthesis under amino acid starvation, regulates proteasomal degradation of cardiac troponin I/TNNI3, and probably of other sarcomeric-associated proteins. TRIM63 may play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. TRIM63 may regulate the organization of myofibrils through TTN in muscle cells. TRIM63 is expressed selectively in heart and skeletal muscle. TRIM63 is also expressed in the iris.

免疫原

KLH-conjugated linear peptide corresponding to the C-terminus of Human TRIM63.

應用

Immunohistochemistry Analysis: A representative lot of this antibody at 20 µg/mL detected Trim63 protein in human cardio myocyte. Similar staining was observed in human skeletal myocyte tissue at 4 µg/mL dilution
This Anti-TRIM63 antibody is validated for use in WB, IH(P) for the detection of TRIM63.

品質

Evaluated by Western Blotting on human skeletal muscle lysate
Western Blotting Analysis: 1 µg/mL dilution of this antibody detected Trim63 protein in 10 µg of human skeletal muscle lysate

標靶描述

~40 kDa observed. Uncharacterized bands may be detected at high antibody concentrations or longer exposures

其他說明

Concentration: Please refer to lot specific datasheet.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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