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生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
human, rat, mouse
技術
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... SLC5A7(60482)
一般說明
蛋白称为胆碱转运体或半胆碱3敏感胆碱转运体（CHT），由基因SLC5A7/CHT1编码，是神经元中的高亲和胆碱转运体。 胆碱是乙酰胆碱合成中的速率限制步骤，一种重要的神经递质。乙酰胆碱是中枢和外周神经系统的神经递质，可调节多种自主，认知和运动功能。 胆碱转运体定位于细胞膜，并在胆碱能神经元中表达，特别是在核壳，脊髓和髓质中。胆碱转运体的缺陷可能与称为声带麻痹的远端型脊髓性肌萎缩综合征有关。胆碱转运体蛋白是一种钠离子和氯离子依赖性转运蛋白，可被纳摩尔浓度的化合物半胆碱3（一种通常用于消耗乙酰胆碱储存的化合物）抑制。
免疫原
GST标记的重组蛋白，对应于人胆碱转运体的C末端。
應用
免疫组化分析：代表性批次的1：500稀释液在大鼠脊髓和人大脑皮质组织中检测到胆碱转运体。
抗胆碱转运体抗体是一种高度特异性的兔多克隆抗体，其靶向胆碱转运体&已在蛋白质印迹&IHC（石蜡）中进行了测试。
品質
通过蛋白质印迹对大鼠脊髓组织裂解物进行了评估。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg大鼠脊髓组织裂解物中检测到胆碱转运体。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg大鼠脊髓组织裂解物中检测到胆碱转运体。
標靶描述
观察值〜70-75 kDa。Uniprot指出MW为~63kDa，但列出了一个糖基化位点，该位点使总MW增加了~5kDa。
聯結
替代品：AB5960；AB5966
其他說明
浓度：请参考批次特异性浓缩物的分析证书。
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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