ABC226

Anti-USP7S Antibody

from rabbit, purified by affinity chromatography

• 别名: Ubiquitin carboxyl-terminal hydrolase 7, Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, Ubiquitin-specific-processing protease 7
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human
• 物種活性（以同源性預測）: Xenopus (based on 100% sequence homology), porcine (based on 100% sequence homology), mouse (based on 100% sequence homology), rat (based on 100% sequence homology)
• 技術: western blot: suitable
• NCBI登錄號: NP_003461
• UniProt登錄號: Q93009
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... USP7(7874)

说明

一般說明

The protein named Ubiquitin carboxyl-terminal hydrolase 7, or Deubiquitinating enzyme 7, Herpesvirus-associated ubiquitin-specific protease, Ubiquitin thioesterase 7, or Ubiquitin-specific-processing protease 7 and encoded by the human gene USP7/HAUSP is a ubiquitin specific hydrolase that deubiquitinates several key transcription factors and thus modulates their activity. Among the important factors are FOXO4, p53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, and DAXX. Thus USP7S is involved in cell proliferation and gene expression regulation and the regulation of the stress response pathways. Interestingly recent research has linked USP7S with regulating transcription-coupled nucleotide excision repair (TC-NER) and the being important in the disease of UV-sensitive syndrome (UVSS) too. USP7S is widely expressed and up regulated in many cancers including prostate cancer.

免疫原

Epitope: N-terminus

KLH-conjugated linear peptide corresponding to a region near the N-terminus of human USP7S.

應用

Anti-USP7S Antibody detects level of USP7S & has been published & validated for use in USP7S.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Western Blotting Analysis: A 1:5,000 dilution of this antibody detected USP7S in HeLa whole cell extract (Dr. Grigory Dianov, University of Oxford, United Kingdom.)

品質

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected USP7S in 10 µg in HeLa cell lysate.

標靶描述

~140 kDa observed

外觀

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable