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生物源
rabbit
品質等級
抗體表格
affinity purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
rat, mouse
製造商／商標名
Chemicon®
技術
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... SCN8A(6334)
一般說明
电压门控钠通道通过在轴突和树突中产生动作电位，在神经系统中对电信号传导起关键作用。至少有10个基因编码哺乳动物中的钠通道，但是区分这些亚型的特定生理作用尚不清楚。 Nav1.6高度集中在外周神经系统感觉轴突和运动轴突的Ranvier音符和中枢神经系统节点上。 由于其一致且受限的标记，抗-Nav1.6（AB5580）已被有效地用作Ranvier标记的节点。
特異性
识别Scn8a（Nav1.6）。该表位对应于Scn8a的II和III结构域之间的细胞内环。不与任何其他已知蛋白发生交叉反应。
物种反应性： 由于序列同源性，预期该抗体对小鼠（20/20）和人（19/20）也有效。其他物种尚未经过测试。
物种反应性： 由于序列同源性，预期该抗体对小鼠（20/20）和人（19/20）也有效。其他物种尚未经过测试。
免疫原
对应于来自小鼠（登录号AAD20438）或大鼠（登录号AAC26014）Scn8a的氨基酸1042-1061的肽。
應用
使用经验证可用于IC、IH &WB的抗SCN8A钠通道抗体检测SCN8A钠通道。
蛋白质印迹：（1：200）在大鼠脑膜上使用ECL。
固定冷冻切片的免疫组化。
大鼠背根神经节原代培养的免疫细胞化学（1：100）
稀释液应使用载体蛋白（例如BSA（1-3%））制备
最佳工作稀释度必须由最终用户确定。
固定冷冻切片的免疫组化。
大鼠背根神经节原代培养的免疫细胞化学（1：100）
稀释液应使用载体蛋白（例如BSA（1-3%））制备
最佳工作稀释度必须由最终用户确定。
其他說明
浓度：请参考批次特异性浓缩物的分析证书。
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Jacy L Wagnon et al.
Neurology. Genetics, 3(4), e170-e170 (2017-07-14)
To determine the functional effect of SCN8A missense mutations in 2 children with intellectual disability and developmental delay but no seizures. Genomic DNA was analyzed by next-generation sequencing. SCN8A variants were introduced into the Nav1.6 complementary DNA by site-directed mutagenesis.
Ping Li et al.
eNeuro, 4(3) (2017-07-01)
The GABA-B receptor is densely expressed throughout the brain and has been implicated in many CNS functions and disorders, including addiction, epilepsy, spasticity, schizophrenia, anxiety, cognitive deficits, and depression, as well as various aspects of nervous system development. How one
Devid Damiani et al.
The Journal of comparative neurology, 520(7), 1406-1423 (2011-11-22)
Retinitis pigmentosa (RP) is a family of inherited diseases causing progressive photoreceptor death. Retinal ganglion cells (RGCs) form the biological substrate for various therapeutic approaches designed to restore vision in RP individuals. Assessment of survival and preservation of RGCs in
Yasmina Manso et al.
Glia, 66(1), 34-46 (2017-07-20)
Chronic cerebral hypoperfusion is a key mechanism associated with white matter disruption in cerebral vascular disease and dementia. In a mouse model relevant to studying cerebral vascular disease, we have previously shown that cerebral hypoperfusion disrupts axon-glial integrity and the
Michell M Reimer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(49), 18185-18194 (2011-12-14)
Myelinated axons have a distinct protein architecture essential for action potential propagation, neuronal communication, and maintaining cognitive function. Damage to myelinated axons, associated with cerebral hypoperfusion, contributes to age-related cognitive decline. We sought to determine early alterations in the protein
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