8.51200

DOTA-tris(tert-butyl ester)

Novabiochem^®

• 别名: DOTA-tris(tert-butyl ester), Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate
• 经验公式（希尔记法）: C₂₈H₅₂N₄O₈
• CAS号: 137076-54-1
• 分子量: 572.73
• MDL號碼: MFCD02259697
• 分類程式碼代碼: 12352108

属性

• 品質等級: 200
• 產品線: Novabiochem^®
• 形狀: powder
• 反應適用性: reagent type: fluorescent-labelling reagent
• 製造商／商標名: Novabiochem^®
• mp: 88-93 °C
• 應用: peptide synthesis
• 儲存溫度: 2-8°C
• InChI: 1S/C28H52N4O8/c1-26(2,3)38-23(35)19-30-12-10-29(18-22(33)34)11-13-31(20-24(36)39-27(4,5)6)15-17-32(16-14-30)21-25(37)40-28(7,8)9/h10-21H2,1-9H3,(H,33,34)
• InChI 密鑰: RVUXZXMKYMSWOM-UHFFFAOYSA-N

说明

一般說明

The most convenient reagent for the labeling of a peptide with DOTA ^[1]. This reagent has good solubility in DMF and DCM, and its free carboxyl group can be easily activated using uronium or phosphonium coupling reagents, enabling it to be attached to peptide amino groups. Removal of the t-butyl ester groups from the DOTA occurs during the course of the TFA-mediated cleavage reaction. The progress of the reaction should be monitored as the cleavage of these esters is slow, owing to the proximity of the basic ring nitrogens.

Literature references

^[1] L. M. De León-Rodrýguez & Z. Kovacs (2008) Bioconjugate Chem, 19, 391.

分析報告

Colour (visual): white to grey
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (NMR): ≥ 95.0 %
Identity (NMR): passes test
NMR-spectrum: passes test

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°C）: Not applicable