688100

YC-1

A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase.

• 别名: YC-1, 3-(5ʹ-Hydroxymethyl-2ʹ-furyl)-1-benzylindazole
• 经验公式（希尔记法）: C₁₉H₁₆N₂O₂
• CAS号: 170632-47-0
• 分子量: 304.34
• MDL编号: MFCD06407798
• UNSPSC代码: 12352200

属性

• 质量水平: 100
• 方案: ≥98% (HPLC)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; desiccated; protect from light
• 颜色: off-white to pale yellow
• 溶解性: DMSO: 10 mg/mL; methanol: 5 mg/mL
• 运输: ambient
• 储存温度: −20°C
• InChI: 1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
• InChI key: OQQVFCKUDYMWGV-UHFFFAOYSA-N

说明

一般描述

A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase. Inhibits platelet adhesion to collagen and acts as an antithrombotic agent. Reported to reduce HIF-1α levels and xenograft growth.

生化/生理作用

Cell permeable: no

Primary Target
Activator of soluble guanylyl cyclase

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.

其他说明

Yeo, E.J., et al. 2003. J. Natl Cancer Inst.95, 516.
Mulsch, A., et al. 1997. Br. J. Pharmacol. 120, 681.
Teng, C.M., et al. 1997. Eur. J. Pharmacol. 320, 161.
Wu, C.C., et al. 1997. Biochem. Biophys. Res. Commun. 231, 412.
Wu, C.C., et al. 1995. Br. J. Pharmacol. 116, 1973.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable