616458

TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem

The TGF-β RI Kinase Inhibitor VII, also referenced under CAS 666729-57-3, controls the biological activity of TGF-β RI Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 别名: TGF-β RI Kinase Inhibitor VII - CAS 666729-57-3 - Calbiochem, 1-(2-((6,7-Dimethoxy-4-quinolyl)oxy)-(4,5-dimethylphenyl)-1-ethanone, ALK5 Inhibitor VII
• 经验公式（希尔记法）: C₂₁H₂₁NO₄
• CAS号: 666729-57-3
• 分子量: 351.40
• UNSPSC代码: 12352200

属性

• 质量水平: 100
• 方案: ≥97% (HPLC)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: off-white
• 溶解性: DMSO: 10 mg/mL; ethanol: 2 mg/mL
• 运输: ambient
• 储存温度: 2-8°C

说明

一般描述

A cell-permeable quinoline compound that acts a potent ATP-competitive inhibitor of ALK5/TGF-β Receptor I kinase activity (IC₅₀ = 0.63 µM), while inhibiting c-Src only at higher concentrations (IC₅₀ = 13 µM). Shown to block TGF-β-induced Smad2 phosphorylation and Smad2/3 transcription activity (IC₅₀ = 0.5 and 0.37 µM, respectively) in human lung cancer epithelial cell line A549.

包装

Packaged under inert gas

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Shimizu, T., et al. 2008. J. Med. Chem.51, 3326.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 10-13 - German Storage Class 10 to 13