566325

SIRT1 Inhibitor IV, (S)-35

The SIRT1 Inhibitor IV, (S)-35, also referenced under CAS 848193-72-6, controls the biological activity of SIRT1. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 别名: SIRT1 Inhibitor IV, (S)-35, (6 S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxamide
• 经验公式（希尔记法）: C₁₄H₁₅ClN₂O
• CAS号: 848193-72-6
• 分子量: 262.73
• MDL號碼: MFCD11045286
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥96% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: DMSO: 10 mg/mL; ethanol: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1
• InChI 密鑰: ABIVOOWWGYJNLV-JTQLQIEISA-N

说明

一般說明

A cell-permeable entiomerically pure compound that is structurally similar to and exhibits similar potency (IC₅₀ = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No. 566322). Shown to be orally bioavailable with a serum half-life of 94 min in mice in vivo.

A cell-permeable entiomerically pure compound that is structurally similar to and exhibits similar potency (IC₅₀ = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No. 566322). Shown to be orally bioavailable with a serum half-life of 94 minutes in mice in vivo.

包裝

Packaged under inert gas

警告

Toxicity: Harmful (C)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Napper, A.D., et al. 2005. J. Med. Chem.48, 8045.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3