557353

RORγ Inverse Agonist, SR2211

The RORγ Inverse Agonist, SR2211 controls the biological activity of RORγ.

• 别名: RORγ Inverse Agonist, SR2211, 1,1,1,3,3,3-hexafluoro-2-(2-fluoro-4′-((4-(pyridin-4-ylmethyl)piperazin-1-yl)methyl)-[1,1′-biphenyl]-4-yl)propan-2-ol, SR-2211, SR 2211
• 经验公式（希尔记法）: C₂₆H₂₄F₇N₃O
• CAS号: 1359164-11-6
• 分子量: 527.48
• MDL编号: MFCD25563263
• UNSPSC代码: 12352200

属性

• 质量水平: 100
• 方案: ≥99% (HPLC)
• 表单: powder
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: white
• 溶解性: DMSO: 50 mg/mL
• 运输: ambient
• 储存温度: 2-8°C
• SMILES字符串: FC1=CC(C(O)(C(F)(F)F)C(F)(F)F)=CC=C1C2=CC=C(CN3CCN(CC4=CC=NC=C4)CC3)C=C2

说明

一般描述

A cell-permeable, piperazine containing biphenyl compound that binds directly to retinoic acid receptor related orphan receptor γ (RORg) and acts as a highly selective and inverse agonist (K_i = 105 nM; IC₅₀ ~ 320 nM). Reported to block the transcriptional activity of RORg and suppress the synthesis of IL-17 in EL-4 murine lymphoma cell line. Exhibits only a minimal effect on RORa and LXRa activity.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Kumar, N., et al. 2012. ACS Chem. Biol.7, 672.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable