推荐产品
品質等級
化驗
≥95% (HPLC)
形狀
powder
效力
2 μM IC50
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
white
溶解度
water: 5 mg/mL
運輸包裝
dry ice
儲存溫度
−20°C
一般說明
An S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.
生化／生理作用
Primary Target
RAGE
RAGE
Reversible: yes
包裝
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
序列
Ac-ELKVLMEKEL-NH2
外觀
Supplied as a trifluoroacetate salt.
重構
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他說明
Arumugam, T., et al. 2012. Clin Cancer Res.18, 4356.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Helena Choltus et al.
International journal of molecular sciences, 22(15) (2021-08-08)
Maternal smoking is a risk factor of preterm prelabor rupture of the fetal membranes (pPROM), which is responsible for 30% of preterm births worldwide. Cigarettes induce oxidative stress and inflammation, mechanisms both implicated in fetal membranes (FM) weakening. We hypothesized
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