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Merck
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主要文件

537075

Sigma-Aldrich

(±)-Propranolol, Hydrochloride

A highly lipophilic agent that blocks both β₁ and β₂ adrenergic receptors with equal potency.

别名:

(±)-Propranolol, Hydrochloride, (±)-1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol, HCl

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About This Item

经验公式（希尔记法）:
C16H21NO2 · xHCl
CAS号:
3506-09-0
分子量:
259.34 (free base basis)
UNSPSC代码:
12352200

质量水平

100

方案

≥97% (HPLC)

表单

powder

制造商/商品名称

Calbiochem®

储存条件

OK to freeze

颜色

white

溶解性

methanol: soluble
water: soluble

运输

ambient

储存温度

−20°C

InChI

1S/C17H23NO2.ClH/c1-13(2)10-18-11-15(19)12-20-17-9-5-7-14-6-3-4-8-16(14)17;/h3-9,13,15,18-19H,10-12H2,1-2H3;1H

InChI key

RTTYPFXTLKDXPS-UHFFFAOYSA-N

一般描述

A highly lipophilic agent that blocks both β1 and β2 adrenergic receptors with equal potency. Has no effect on α-adrenergic receptors. Also binds to 5HT-1B receptors with high affinity (Ki = 17 nM) in contrast to 5HT-1D receptors (Ki = 10.2 µM). Readily enters the central nervous system. Blocks phospholipase D-derived diacylglycerol (DAG) formation by inhibiting phosphatidate phosphohydrolase. Useful tool for discriminating between phospholipase D- or phospholipase C-mediated DAG production. An anti-hypertensive agent that is also used in the treatment of cardiac arrhythmias.

生化/生理作用

Cell permeable: no
Primary Target
β1 and β2 adrenergic receptors
Product does not compete with ATP.
Reversible: no
Target Ki: 17 nM for 5HT-1B receptors

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C).

其他说明

Fujita, K., et al. 1996. FEBS Lett.395, 293.
Glennon, R.A., et al. 1996. Mol. Pharmacol.49, 198.
Thompson, N.T., et al. 1991. Trends Pharmacol. Sci.12, 404.
Hoffman, B.B., and Lefkowitz, R.J. 1990. in The Pharmacological Basis of Therapeutics (Gilman, A.G., et al., Eds.) p. 221, Pergamon Press, New York.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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