5.31620

APT1 Inhibitor II, Cpd21

• 别名: APT1 Inhibitor II, Cpd21, LYPLA1 Inhibitor, Lysophospholipase Inhibitor
• 经验公式（希尔记法）: C₁₈H₁₇ClF₃N₃O₃
• CAS号: 899713-86-1
• 分子量: 415.79
• MDL编号: MFCD05123530
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 方案: ≥98% (HPLC)
• 质量水平: 100
• 表单: solid
• 效能: 840 nM IC₅₀
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: white
• 溶解性: DMSO: 50 mg/mL
• 储存温度: 2-8°C
• SMILES字符串: FC(F)(F)c1cc(c(cc1)Cl)NC(=O)CN2CCN(CC2)C(=O)c3[o]ccc3
• InChI: 1S/C18H17ClF3N3O3/c19-13-4-3-12(18(20,21)22)10-14(13)23-16(26)11-24-5-7-25(8-6-24)17(27)15-2-1-9-28-15/h1-4,9-10H,5-8,11H2,(H,23,26)
• InChI key: OXKNHBBDOIMFFQ-UHFFFAOYSA-N

说明

一般描述

A cell permeable acetylpiperazine derivative compound that acts as a selective and reversible inhibitor of lysophospholipase 1 (LYPLA1; IC₅₀ = 840 nM, K_i = 300 nM) without affecting the activity of LYPLA2 and 25 other serine hydrolases in mouse BW5147 T cell hydridoma proteome. Shown to cause an almost complete inhibition (+90%) of LYPLA1 activity in lung, heart, and kidney (50 mg/kg, 3 h), and in HEK293T, and mouse T cells (~ 5 µM for 3 h).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

生化/生理作用

Cell permeable: yes

Primary Target
APT1

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Adibekian, A., et al. 2012. J. Am. Chem. Soc.134, 10345.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable