5.08514

Psalmotoxin-1

• 别名: Psalmotoxin-1, ASIC1a Inhibitor, Psalmotoxin 1
• 经验公式（希尔记法）: C₂₀₀H₃₁₂N₆₂O₅₇S₆
• CAS号: 316808-68-1
• 分子量: 4689.39
• MDL编号: MFCD00004691
• UNSPSC代码: 12352200
• NACRES: NA.77

属性

• 方案: ≥94% (HPLC)
• 质量水平: 100
• 表单: semisolid; viscous liquid
• 效能: 0.9 nM IC₅₀
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; desiccated (hygroscopic); protect from light
• 颜色: colorless
• 储存温度: −20°C

说明

一般描述

A potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC₅₀ = 0.9 nm) isolated from the Trinidad chevron tarantula. Psalmotoxin-1 (PcTx1) can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b. Binding site is blocked when dimerization with ASIC2a or ASIC3.

生化/生理作用

Primary Target
ASIC1a

警告

Toxicity: Standard Handling (A)

序列

EDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (disulfide bond 3-18, 10-23, 17-33)

其他说明

Qadri, Y. J. et al. 2009. J. Biol. Chem.284, 17625.
M. Mazzuca, et al. 2007. Nat Neurosci.10, 943.
Escoubas, P. et al. 2000. J. Biol. Chem.275, 25116.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable