5.08410

Glycogen Phosphorylase Inhibitor II, KB228

• 别名: Glycogen Phosphorylase Inhibitor II, KB228, KB-228
• 经验公式（希尔记法）: C₁₆H₂₂N₂O₇
• CAS号: 1595277-35-2
• 分子量: 354.36
• MDL编号: MFCD00000133
• UNSPSC代码: 51111800
• NACRES: NA.77

属性

• 方案: ≥98% (HPLC)
• 质量水平: 100
• 表单: powder
• 效能: 930 nM K_i
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: white
• 溶解性: DMSO: 100 mg/mL
• 储存温度: −20°C

说明

一般描述

A glucopyranosyl urea compound that acts as an inhibitor of muscle glycogen phosphorylase (K_i = 930 nM). Displays a mixed type of inhibition. Enhances glucose sensitivity in chow-fed, obese, diabetic mice and increasing hepatic glucose uptake. Reduces blood glucose levels and increases hepatic glycogen content in C57/BL6J mice. Shown to increase mitochondrial oxidation in Hep2G cells under normoglycemic conditions. Enhances the expression of uncoupling proteins2 (UCP2) in HepG2 cells. This effect was less pronounced under hyperglycemic conditions.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

生化/生理作用

Cell permeable: yes

Primary Target
Glycogen Phosphorylase

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Nagy, L., et al. 2013. PLoS One.8, e69420.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable