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Merck
所有图片(1)

主要文件

5.08410

Sigma-Aldrich

Glycogen Phosphorylase Inhibitor II, KB228

别名:

Glycogen Phosphorylase Inhibitor II, KB228, KB-228

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About This Item

经验公式(希尔记法):
C16H22N2O7
分子量:
354.36
MDL编号:
UNSPSC代码:
51111800
NACRES:
NA.77

方案

≥98% (HPLC)

质量水平

表单

powder

效能

930 nM Ki

制造商/商品名称

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

white

溶解性

DMSO: 100 mg/mL

储存温度

−20°C

一般描述

A glucopyranosyl urea compound that acts as an inhibitor of muscle glycogen phosphorylase (Ki = 930 nM). Displays a mixed type of inhibition. Enhances glucose sensitivity in chow-fed, obese, diabetic mice and increasing hepatic glucose uptake. Reduces blood glucose levels and increases hepatic glycogen content in C57/BL6J mice. Shown to increase mitochondrial oxidation in Hep2G cells under normoglycemic conditions. Enhances the expression of uncoupling proteins2 (UCP2) in HepG2 cells. This effect was less pronounced under hyperglycemic conditions.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

生化/生理作用

Cell permeable: yes
Primary Target
Glycogen Phosphorylase
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Nagy, L., et al. 2013. PLoS One.8, e69420.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Lilla Nagy et al.
PloS one, 8(7), e69420-e69420 (2013-08-13)
Glycogen phosphorylase (GP) catalyzes the breakdown of glycogen and largely contributes to hepatic glucose production making GP inhibition an attractive target to modulate glucose levels in diabetes. Hereby we present the metabolic effects of a novel, potent, glucose-based GP inhibitor

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