5.08150

LY 344864 Hydrochloride

• 别名: LY 344864 Hydrochloride, 5-HT _1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864, 5-HT_1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864
• 经验公式（希尔记法）: C₂₁H₂₂FN₃O · xHCl
• CAS号: 186544-26-3
• 分子量: 351.42 (free base basis)
• 分類程式碼代碼: 12352200

属性

• 化驗: ≥98% (HPLC)
• 品質等級: 100
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: water: 10 mM; DMSO: 100 mM
• 儲存溫度: 2-8°C
• InChI: 1S/C21H22FN3O.ClH/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13;/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26);1H/t16-;/m1./s1
• InChI 密鑰: OKUHLSYESBLBCP-PKLMIRHRSA-N

说明

一般說明

A selective, brain penetrant, full agonist for the 5-HT_1F receptor (pKi = 8.2). It possesses little affinity for the 56 other serotonergic and non-serotonergic neuronal binding sites examined. When examined for its ability to inhibit forskolin-induced cyclic AMP accumulation in cells stably transfected with human 5-HT_1F receptors, LY344864 was shown to be a full agonist producing an effect similar in magnitude to serotonin itself. Suitable for both in vitro and in vivo applications and its effects are often reversed with the 5-HT_1B/1D antagonist GR 127935 (Cat. No. 508014)

生化／生理作用

Primary Target
5-HT_1F

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Amrutkar, D. V. et al. 2012. Pain.153, 830.

Phebus, L. A. et al. 1997. Life Sci.61, 2117.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable