5.06047

3,3′-Diamino-4′-methoxyflavone, DD1

• 别名: 3,3′-Diamino-4′-methoxyflavone, DD1, 3-amino-2-(3-amino-4-methoxyphenyl)-4H-chromen-4-one, p76S6 Inhibitor, DD1, Proteasome Inhibitor, DD1
• 经验公式（希尔记法）: C₁₆H₁₄N₂O₃
• 分子量: 282.29
• UNSPSC代码: 12352200

属性

• 方案: ≥98% (HPLC)
• 质量水平: 200
• 表单: powder
• 效能: 2 μM IC₅₀
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: yellow
• 溶解性: DMSO: 100 mg/mL
• 储存温度: 2-8°C

说明

一般描述

A cell-permeable flavone derivative that arrests the proliferation of acute myeloid leukemia cells (NB4, U937, HL-60, OCI AML3), in a dose and time-dependent manner (optimum at ~20 µM and 96 h) and blocks the colony formation in samples from acute myeloid leukemia patients, without affecting normal blood cells. Shown to reduce mitochondrial membrane potential and Bad phosphorylation (at Ser136), induce Bax and caspase 3, 8, and 9 activation in U937 cells. Does not affect the phosphorylation of Akt1, but significantly reduces the expression and phosphorylation of p70S6 kinase in U937 cells. Reported to inhibit the chymotrypsin-like activity of proteasome (IC₅₀ = 2.0 µM) and this effect is synergistic with bortezomib (Cat. No. 504314).

生化/生理作用

Cell permeable: yes

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他说明

Piedfer. M., et al, 2013. Biochim. Biophys. Acta.1833,1316
Quiney, C., et al, 2004. Leuk. Res.28, 851.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable