跳转至内容
Merck
所有图片(1)

文件

5.05896

Sigma-Aldrich

Sumanirole Maleate

别名:

Sumanirole Maleate, Dopamine D₂ receptor Agonist, Sumanirole, PNU 95666, PNU95666

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C11H13N3O · xC4H4O4
CAS号:
179386-44-8
分子量:
203.24 (free base basis)
MDL號碼:
MFCD09832637
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥98% (HPLC)

品質等級

100

形狀

solid

效力

9 nM Ki

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

off-white

溶解度

DMSO: 16 mg/mL

儲存溫度

−20°C

InChI

1S/C11H13N3O.C4H4O4/c1-12-8-5-7-3-2-4-9-10(7)14(6-8)11(15)13-9;5-3(6)1-2-4(7)8/h2-4,8,12H,5-6H2,1H3,(H,13,15);1-2H,(H,5,6)(H,7,8)/b;2-1-/t8-;/m1./s1

InChI 密鑰

VOJRMYBBPKNLLI-ORHWHDKWSA-N

一般說明

An extremely selective dopamine D2 receptor agonist (Ki = 9 nM). Commonly used in Parkinson′s Disease models and to reproduce cocaine′s discriminative stimulus effects. Sumanirole has greater than 200-fold selectivity for the D2 receptor subtype versus the other dopamine receptor subtypes in radioligand binding assays. In cell-based assays, sumanirole is a fully efficacious agonist, with EC50 values between 17 and 75 nM. In animals, sumanirole elicits many physiological responses attributed to D2-like receptor function.

警告

Toxicity: Standard Handling (A)

其他說明

Achat-Mendes, C. et al., 2010. J. Pharmacol. Exp. Ther.334, 556.
McCall, R. B. et al., 2005. J. Pharmacol. Exp. Ther.314, 1248.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Robert B McCall et al.
The Journal of pharmacology and experimental therapeutics, 314(3), 1248-1256 (2005-06-28)
The purpose of this study is to demonstrate that sumanirole is a novel dopamine receptor agonist with high in vitro and in vivo selectivity for the D(2) receptor subtype. Sumanirole, (R)-5,6-dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Z)-2-butenedioate (1:1), is unique; it has greater than 200-fold
Cindy Achat-Mendes et al.
The Journal of pharmacology and experimental therapeutics, 334(2), 556-565 (2010-05-25)
Dopamine (DA) D3 and D2 receptor mechanisms are implicated in cocaine's abuse-related behavioral effects, but the relative contribution of the two receptor subtypes is only partially characterized. This study investigated the role of D3 and D2 subtype mechanisms by determining

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门