5.04479

JNJ 16259685 - CAS 409345-29-5 - Calbiochem

• 别名: JNJ 16259685 - CAS 409345-29-5 - Calbiochem, (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
• 经验公式（希尔记法）: C₂₀H₂₃NO₃
• CAS号: 409345-29-5
• 分子量: 325.40
• UNSPSC代码: 12352200

属性

• 方案: ≥98% (TLC)
• 质量水平: 100
• 表单: solid
• 效能: 0.55 nM IC₅₀; 0.34 nM K_i
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: white to off-white
• 溶解性: DMSO: 25 mM
• 储存温度: 2-8°C

说明

一般描述

An extremely potent, non-competitive antagonist for mGlu receptor subtype 1 (K_i = 0.34 nM; IC₅₀ = 0.55 nM). 400-fold more selective for mGlu₁ than for mGlu₅ and no interaction with mGlu₂, mGlu₃, mGlu₄, mGlu₆, AMPA or NMDA receptors (IC₅₀ >10 µM). Centrally active following systemic administration. Widely used for studying substance abuse, learning and memory, and neural plasticity.

生化/生理作用

Primary Target
mGlu₁

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Lavreysen, H., et al. 2004. Neuropharmacology.47, 961.

Steckler, T., et al. 2005. Psychopharmacology.179, 198.

Steckler, T., et al. 2005. Behav. Brain. Res.164, 52.

Mabire, D., et al. 2005. J. Med. Chem.48, 2134.
Fukunaga, I., et al. 2007. Br. J. Pharmacol.151, 870.

Knopfel, T., et al. 2007. Br. J. Pharmacol.151, 723.

Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther.343, 214.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany