5.00554

MHY1485

≥97% (HPLC), solid, mTOR activator, Calbiochem^®

• 别名: mTOR活化剂，MHY1485
• 经验公式（希尔记法）: C₁₇H₂₁N₇O₄
• CAS号: 326914-06-1
• 分子量: 387.39
• 分類程式碼代碼: 12352200
• PubChem物質ID: 2026662
• NACRES: NA.77

属性

• product name: mTOR活化剂，MHY1485,
• 化驗: ≥97% (HPLC)
• 品質等級: 100
• 形狀: solid
• 效力: ~2 μM IC₅₀
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: pale yellow
• 溶解度: DMSO: 12.5 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC(=NN3)C4=CC=CC=C4O

说明

一般說明

MHY1485, a small-molecule activator of the mammalian target of rapamycin (mTOR), exerts an inhibitory effect on the autophagic process by preventing the fusion between autophagosomes and lysosomes, resulting in the accumulation of LC3II protein and the enlargement of autophagosomes. It can also protect osteoblasts from dexamethasone-induced damage by inhibiting the mitochondrial death pathway provoked by dexamethasone.

應用

mTOR Activator, MHY1485 has been used to activate the mammalian target of rapamycin (mTOR) pathway in mice with Parkinson disease (PD) to reverse the effects of tumor necrosis factor α–induced protein 3 (TNFAIP3) on the mitigation of injury in mice and in SK-N-SH cells induced with 1-Methyl-4-phenylpyridinium (MPP+).

生化／生理作用

可逆性：是

细胞可渗透性：具有

包裝

用惰性气体包装

警告

毒性：标准处理（A）

重構

溶解后，等分并冷冻保存（-20°C）。储备溶液在-20°C下可稳定保存至多3个月。

其他說明

Choi, Y. J., et al. 2012.PLoS.One.7, e43418.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable