437625

Lipopolysaccharide, E. coli O55: B5 - Calbiochem

Stimulates the activity of inducible nitric oxide synthase.

• UNSPSC代码: 12352200

属性

• 质量水平: 100
• 表单: lyophilized
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze
• 杂质: ≤1.3% nucleic acid; ≤2.0% protein
• 溶解性: water: soluble
• 运输: ambient
• 储存温度: 2-8°C

说明

一般描述

Endotoxin lipopolysaccharides initiate a variety of biochemical cell activation pathways (PKC, cAMP-dependent protein kinase, arachidonate metabolism, protein myristoylation, and activation of G-proteins). These unique macromolecules have been extensively studied in order to elucidate and define relevant pathophysiological parameters of endotoxin shock, a profound life-threatening consequence of bacterial sepsis. More recently, these bacterial products have generated intense interest due to their pluripotential immunostimulatory activity, as manifested by the activation of host cells (e.g. B lymphocytes, macrophages) to functional differentiation. Host cells activated by lipopolysaccharides produce a spectrum of hormone-active lymphokines and monokines, including interferons (α, β, and γ), interleukins (IL-1 and IL-6), tumor necrosis factor, platelet activating factor and procoagulant tissue factor. Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.

Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.

生化/生理作用

Cell permeable: no

Primary Target
Stimulates the activity of inducible nitric oxide synthase

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.

其他说明

Hattori, S., et al. 1995. Biochem. Mol. Biol. Int.35, 177.
Mayeux, P.R., et al. 1995. Biochem. Pharmacol.49, 115.
Norimatsu, M., et al. 1995. Infect. Immun.63, 1122.
Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
Zhang, Y.H., et al. 1993. Infect. Immun.61, 5044.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials