422682

K _ir1.1 Inhibitor, VU591

The K_ir1.1 Inhibitor, VU591 controls the biological activity of K_ir1.1. This small molecule/inhibitor is primarily used for Neuroscience applications.

• 别名: K _ir1.1 Inhibitor, VU591
• 经验公式（希尔记法）: C₁₆H₁₂N₆O₅
• CAS号: 1222810-74-3
• 分子量: 368.30
• 分類程式碼代碼: 12352200

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: light gray
• 溶解度: DMSO: 100 mg/mL, clear, dark brown
• 運輸包裝: ambient
• 儲存溫度: 2-8°C

说明

一般說明

A cell-permeable, benzoimidazole, renal outer medullary potassium channel (ROMK) blocker that selectively inhibits inward rectifier potassium channel, K_ir1.1 (IC₅₀ = 240 nM), in HEK-293 cells. At 10 µM, it displays no effect on Kir2.1, Kir2.3, Kir4.1, and Kir7.1, with 150-fold selectivity over K_ir6.2. In addition, it exhibits a modest off-target effect on the GABA_A receptor (IC₅₀ = 6.2 µM) among a panel of cardiac and central nervous system ion channels and receptors.

The K_ir1.1 Inhibitor, VU591 controls the biological activity of K_ir1.1. This small molecule/inhibitor is primarily used for Neuroscience applications.

包裝

Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Bhave, G., et al. 2011. Mol Pharmacol.79, 42.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable