推荐产品
品質等級
化驗
≥95% (HPLC)
形狀
liquid
製造商/商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
溶解度
DMSO: soluble
運輸包裝
wet ice
儲存溫度
−20°C
InChI
1S/C32H31N3O5/c1-3-4-5-10-15-39-30(37)32(38)16-23-34-21-13-8-6-11-18(21)25-26-20(17-33-29(26)36)24-19-12-7-9-14-22(19)35(28(24)27(25)34)31(32,2)40-23/h6-9,11-14,23,38H,3-5,10,15-17H2,1-2H3,(H,33,36)/t23-,31+,32+/m0/s1
InChI 密鑰
ZHEHVZXPFVXKEY-RUAOOFDTSA-N
生化/生理作用
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target Ki: 56 nM against protein kinase A
包裝
Packaged under inert gas
警告
Toxicity: Irritant (B)
外觀
A 2 mM (50 µg/47 µl) solution of KT 5720 (Cat. No. 420320) in DMSO.
重構
Following the initial thaw, aliquot and freeze (20°C).
其他說明
Simpson, C.S., and Morris, B.J. 1995. Neurosci.68, 97.
Cabell, L, and Audesirk, G. 1993. Int. J. Dev. Neurosci.11, 357.
Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA89, 8626.
Kase, H., et al. 1987. Biochem. Biophys. Res. Commun.142, 436.
Cabell, L, and Audesirk, G. 1993. Int. J. Dev. Neurosci.11, 357.
Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA89, 8626.
Kase, H., et al. 1987. Biochem. Biophys. Res. Commun.142, 436.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 1
閃點(°F)
188.6 °F - (refers to pure substance)
閃點(°C)
87 °C - (refers to pure substance)
Molecular cell, 82(20), 3794-3809 (2022-10-08)
Neuronal activity induces topoisomerase IIβ (Top2B) to generate DNA double-strand breaks (DSBs) within the promoters of neuronal early response genes (ERGs) and facilitate their transcription, and yet, the mechanisms that control Top2B-mediated DSB formation are unknown. Here, we report that
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