361563

GSK-3 Inhibitor XXII, Compound A

• 别名: GSK-3 Inhibitor XXII, Compound A, 6-Methyl-N-[3-[[3-(1-methylethoxy)propyl]carbamoyl]-1H-pyrazol-4-yl]pyridine-3-carboxamide
• 经验公式（希尔记法）: C₁₇H₂₃N₅O₃
• 分子量: 345.40
• UNSPSC代码: 12352200

属性

• 方案: ≥95% (HPLC)
• 质量水平: 100
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; protect from light
• 颜色: green-gray
• 溶解性: DMSO: 50 mg/mL
• 运输: ambient
• 储存温度: 2-8°C

说明

一般描述

A cell-permeable pyrazolopyridine compound that acts as a potent inhibitor against both GSK-3α and GSK-3β (IC₅₀ = 2.3 and 2 nM, respectively, in the presence of 0.5 µM of ATP) with much reduced or little activity toward a panel of 27 other commonly studied kinases. Shown to selectively inhibit the phosphorylation of cellular tau on GSK-specific serine/threonine residues, but not those targeted by non-GSK kinases, both in primary rat cortical neuron cultures (up to 30 µM) in vitro and in mice (up to 26 mg/kg/day p.o.) in vivo. Chronic oral treatment of compound A is also reported to significantly reduce insoluble tau aggregate formation by up to 70% (26 mg/kg/day p.o.) in brain tissues from JNPL3 mice expressing human 4R0N tau with a FTDP-17 (P301L) mutation.

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他说明

Uno. Y., et al. 2009. Brain Res.1296, 148.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable